568500
SQ 22536
≥98% (HPLC), adenylate cyclase inhibitor, solid
Synonym(s):
SQ 22536, 9-(Tetrahydro-2ʹ-furyl)adenine
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About This Item
Empirical Formula (Hill Notation):
C9H11N5O
CAS Number:
Molecular Weight:
205.22
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Product Name
SQ 22536, Cell-permeable adenylate cyclase inhibitor.
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
off-white
solubility
DMSO: 25 mg/mL, water: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
[n]2(c3ncnc(c3nc2)N)C1OCCC1
InChI
1S/C9H11N5O/c10-8-7-9(12-4-11-8)14(5-13-7)6-2-1-3-15-6/h4-6H,1-3H2,(H2,10,11,12)
InChI key
UKHMZCMKHPHFOT-UHFFFAOYSA-N
General description
Cell-permeable adenylate cyclase inhibitor. Blocks PTH-stimulation of adenylate cyclase (IC50 = 200 µM). Reduces PGE2-induced inhibition of O2·– production.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
adenylate cyclase
adenylate cyclase
Product does not compete with ATP.
Reversible: no
Target IC50: 200 µM against adenylate cyclase
Preparation Note
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.
Other Notes
Talpain, E., et al. 1995. Br. J. Pharmacol. 114, 1459.
Tamaoki, J., et al. 1993. Prostaglandins45, 363.
Fabbri, E., et al. 1991. J. Enzyme Inhib.5, 87.
Goldsmith, B.A. and Abrams, T.W. 1991. Proc. Natl. Acad. Sci. USA 88, 9021.
Tamaoki, J., et al. 1993. Prostaglandins45, 363.
Fabbri, E., et al. 1991. J. Enzyme Inhib.5, 87.
Goldsmith, B.A. and Abrams, T.W. 1991. Proc. Natl. Acad. Sci. USA 88, 9021.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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NaHye Lee et al.
The FEBS journal, 287(17), 3841-3870 (2020-02-01)
Microglia (MG), the principal neuroimmune sentinels in the brain, continuously sense changes in their environment and respond to invading pathogens, toxins, and cellular debris, thereby affecting neuroinflammation. Microbial pathogens produce small metabolites that influence neuroinflammation, but the molecular mechanisms that
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 568500-5MG | 04055977190397 |