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648311

Tris Base

Name: Tris Base
Brand: MM

≥99% dry basis (titration), crystalline solid, pH 10.3-11.3, Ultrol^® Grade

Synonym(s):

Tris(hydroxymethyl)aminomethane, tris(Hydroxymethyl)aminomethane, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol

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About This Item

Linear Formula:

NH₂C(CH₂OH)₃

CAS Number:

77-86-1

Molecular Weight:

121.14

UNSPSC Code:

12161705

NACRES:

NA.25

MDL number:

MFCD00004679

Beilstein/REAXYS Number:

741883

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Properties

Product Name

Tris Base, ULTROL^® Grade, ≥99% dry basis (titration), useful in pH range 10.3-11.3

description

Merck USA index - 14, 9772

Quality Level

100

assay

≥99% dry basis (titration)

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

useful pH range

7-9

pKa (25 °C)

8.1

bp

219-220 °C/10 mmHg (lit.)

mp

167-172 °C (lit.)

solubility

water: 1 M

cation traces

heavy metals: ≤5 ppm

shipped in

ambient

storage temp.

10-30°C

SMILES string

NC(CO)(CO)CO

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

Description

General description

Absorbance (1.0 M, H₂O, 260 nm): <0.05.

Useful in the pH range of 10.3-11.3. Has a pK_a of 8.1 at 25°C.

Widely used as a biological buffer (absorbance: <0.05 at 260 nm, 1.0 M, H₂O). A 1.0 M solution in H₂O has a pH range of 10.3-11.3 and a pK_a of 8.3 at 20°C.

Application

Development of an Antigen Capture Lateral Flow Immunoassay for the Detection of Burkholderia pseudomallei.: This study uses Tris Base in the development of a lateral flow immunoassay for detecting Burkholderia pseudomallei, enhancing diagnostic capabilities in clinical microbiology (Nualnoi et al., 2024).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

ULTROL is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)

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wgk

WGK 1

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c