Key Documents

View All Documentation

ABN278

Anti-Prospero homeobox protein 1/PROX1 Antibody

Name: Anti-Prospero homeobox protein 1/PROX1 Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Synonym(s):

Prospero homeobox protein 1, Homeobox prospero-like protein PROX1, PROX-1

Select a Size

Change View

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC, WB

Citations:

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat

species reactivity (predicted by homology)

bovine (based on 100% sequence homology), fish (based on 100% sequence homology), chicken (based on 100% sequence homology), human (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

NP_001257545

UniProt accession no.

Q92786

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Prox1(19130)

Description

General description

PROX1 (Prospero homeobox protein 1), the homolog of Drosophila Prospero, is a homeobox-containing transcription factor that binds and functions as a co-receptor of liver receptor homolog 1 (LRH1/NR5A2). It is a specific marker for lymphatic endothelial cells, as well as hepatoblasts and hepatocytes. Human Prox1 shares 97% amino acid sequence identity with mouse and rat Prox1.

~95 kDa observed. Uniprot describes a molecular weight at 83 kDa However, this protein may be observed between 80-110 kDa due to sumoylation and/or alternative start sites (Pan, M. R., et al. (2009). J Cell Sci. 122(Pt18):3358-3361.; Azuma, K., et al. (2011). Genes Cells. 16(11):1063-1070.).

Immunogen

KLH-conjugated linear peptide corresponding to the C-terminus of human Prospero homeobox protein 1/PROX1.

Application

Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Prospero homeobox protein 1/PROX1 in mouse E16 embryo thalamus tissues (Prof. Samual Pleasure, University of California, San Francisco.).

Alexa Fluor^™ is a registered trademark of Life Technologies, Inc.

This Anti-Prospero homeobox protein 1/PROX1 Antibody is validated for use in western blotting & IHC for the detection of Prospero homeobox protein 1/PROX1.

Analysis Note

Evaluated by Western Blotting in HEK293 nuclear extract.

Western Blotting Analysis: A 1:500 dilution of this antibody detected Prospero homeobox protein 1/PROX1 in 10 µg of HEK293 nuclear extract.

Other Notes

Replaces: AB5475

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Hemispheric cortical atrophy and chronic microglial activation following mild focal ischemic stroke in adult male rats.

Charlotte M Ermine et al.

Journal of neuroscience research, 99(12), 3222-3237 (2021-10-16)

Animal modeling has played an important role in our understanding of the pathobiology of stroke. The vast majority of this research has focused on the acute phase following severe forms of stroke that result in clear behavioral deficits. Human stroke

Modelling the dopamine and noradrenergic cell loss that occurs in Parkinson's disease and the impact on hippocampal neurogenesis.