03641
Dansyl chloride
LiChropur™, ≥99.0% (HPLC)
Synonym(s):
5-(Dimethylamino)naphthalene-1-sulfonyl chloride, DNSCl
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About This Item
Empirical Formula (Hill Notation):
C12H12ClNO2S
CAS Number:
Molecular Weight:
269.75
UNSPSC Code:
41116105
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-092-6
Beilstein/REAXYS Number:
2217205
MDL number:
grade
derivatization grade ((HPLC))
Quality Level
assay
≥99.0% (HPLC)
form
powder or crystals
quality
LiChropur™
technique(s)
HPLC: suitable
mp
72-74 °C (lit.)
solubility
acetone: 0.2 g/10 mL, clear to slightly turbid, yellow to very dark yellow-orange
storage temp.
2-8°C
SMILES string
CN(C)c1cccc2c(cccc12)S(Cl)(=O)=O
InChI
1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3
InChI key
XPDXVDYUQZHFPV-UHFFFAOYSA-N
General description
Dansyl chloride is a fluorogenic reagent which is typically employed for the derivatization of amino acids.
Application
Dansyl chloride has been used for the fluorogenic labeling of xenoestrogens, 4-nonylphenol and bisphenol A prior to their determination by high-performance liquid chromatography (HPLC) with fluorescence detection. It has also been used for the derivatization of icariin in human serum samples after oral administration of Epimedium decoction, followed by its determination using ultrasensitive LC-tandem mass spectrometry (LC-MS) and for the derivatization of antitumoral agent ES-285 in dog plasma followed by its analysis by HPLC equipped with ultraviolet and fluorescence detection.
A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
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Phenylisothiocyanate and dansyl chloride precolumn derivatizations for the high-performance liquid chromatography analysis of the antitumoral agent ES-285 in dog plasma.
Maraschiello, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 791(1-2), 1-11 (2003)
Trace analysis of icariin in human serum with dansyl chloride derivatization after oral administration of Epimedium decoction by liquid chromatography tandem mass spectrometry.
Gong, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 860(2), 166-172 (2007)
Determination of the xenoestrogens 4-nonylphenol and bisphenol A by high-performance liquid chromatography and fluorescence detection after derivatisation with dansyl chloride.
Naassner, et al.
Journal of Chromatography A, 945(1-2), 133-138 (2002)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 03641-100MG | 04061838619747 |
| 03641-10X100MG | 04061838619754 |