04704
Glycidamide
analytical standard
Synonym(s):
2,3-Epoxypropanamide, Oxiranecarboxamide
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About This Item
Empirical Formula (Hill Notation):
C3H5NO2
CAS Number:
Molecular Weight:
87.08
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
227-163-2
Beilstein/REAXYS Number:
227 163 2
MDL number:
grade
analytical standard
Quality Level
assay
≥95% (qNMR)
shelf life
limited shelf life, expiry date on the label
application(s)
environmental
format
neat
storage temp.
2-8°C
SMILES string
NC(=O)C1CO1
InChI
1S/C3H5NO2/c4-3(5)2-1-6-2/h2H,1H2,(H2,4,5)
InChI key
FMAZQSYXRGRESX-UHFFFAOYSA-N
General description
Glycidamide, an active epoxide metabolite of acrylamide with potential biological activity, can be generated in vivo. Its mutagenic and genotoxic nature is well-known.
Application
Glycidamide may be used as an analytical standard for the determination of the analyte in human and animal biological samples by various chromatography techniques.
Other Notes
In the summer of 2008 research scientists at the Technical University of Munich besides acrylamide detected glycidamide in potato crisps. Glycidamide is a metabolite of acrylamide.
signalword
Danger
Hazard Classifications
Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Natalia Kotova et al.
Toxicology letters, 207(1), 18-24 (2011-09-01)
Acrylamide (AA) is produced in many types of food products cooked or processed at high temperature. AA is metabolized to the epoxide glycidamide (GA), which can bind to deoxyguanosine and deoxyadenosine in DNA. The GA-derived N7-guanine and N3-adenine adducts are
Anja Olsen et al.
Toxicology, 296(1-3), 67-72 (2012-04-03)
Acrylamide is a probable human carcinogen, with industrial contact, tobacco smoking and foods processed at high temperatures as the main routes of exposure. In animal studies oral intake of acrylamide has been related to cancer development, with indications that the
Rui-Sheng Wang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 117(1), 72-80 (2010-06-29)
Acrylamide (AA) is an industrial chemical, a by-product of fried starchy foods, and a mutagen and rodent carcinogen. It can also cause damage during spermatogenesis. In this study, we investigated whether AA and its metabolite glycidamide (GA) induce mutagenic effects
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 76512-10MG | 04061832385853 |
| 76512-50MG | 04061832923284 |
| 04704-100MG | 04061838635686 |