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15222

BSTFA

derivatization grade (GC derivatization), LiChropur™, ≥99.0%

Synonym(s):

BSTFA

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About This Item

Linear Formula:
CF3C[=NSi(CH3)3]OSi(CH3)3
CAS Number:
25561-30-2
Molecular Weight:
257.40
NACRES:
NA.22
PubChem Substance ID:
329750779
UNSPSC Code:
41116105
EC Number:
247-103-9
MDL number:
MFCD00008269
Beilstein/REAXYS Number:
2050024
Assay:
≥99.0% (GC), ≥99.0%
Form:
liquid
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Product Name

N,O-Bis(trimethylsilyl)trifluoroacetamide, derivatization grade (GC derivatization), LiChropur™, ≥99.0%

grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥99.0% (GC), ≥99.0%

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.384

bp

45-50 °C/14 mmHg (lit.)

density

0.969 g/mL at 25 °C (lit.)

SMILES string

C[Si](C)(C)O\C(=N\[Si](C)(C)C)C(F)(F)F

InChI

1S/C8H18F3NOSi2/c1-14(2,3)12-7(8(9,10)11)13-15(4,5)6/h1-6H3/b12-7+

InChI key

XCOBLONWWXQEBS-KPKJPENVSA-N

General description

N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions. BSTFA finds application in derivatizing amines. It is suitable for silyaltion of carboxylic acids, phenols, ureas, amides and alcohols.

Application

Learn more in the Product Information
BSTFA + 1% TMCS (trimethylsilyl) in ethyl acetate, acetonitrile and dichloromethane solvents may be used for silylation of steroid hormone 17a-ethinylestradiol (EE2) using gas chromatography-mass spectrometry (GC-MS). It may also be used for silylation of endogenous 2-monoglyceride, present in canine gut that binds to cannabinoid receptors.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

93.2 °F

flash_point_c

34 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG6240
BCCG0537
BCCF4823
BCCD2608
BCCC4416

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Articles

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

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Schirmer RE.
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R Mechoulam et al.
Biochemical pharmacology, 50(1), 83-90 (1995-06-29)
In this study, we report the isolation from canine intestines of 2-arachidonyl glycerol (2-Ara-Gl). Its structure was determined by mass spectrometry and by direct comparison with a synthetic sample. 2-Ara-Gl bound to membranes from cells transiently transfected with expression plasmids
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Global Trade Item Number

SKUGTIN
15222-25ML-F04061837683435
15222-10X1ML-F04061838740267
15222-1ML-F04061838740274
15222-5ML-F04061837683442