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15269

N,O-Bis(trimethylsilyl)acetamide

derivatization grade (GC derivatization), LiChropur™, ≥98.5% (GC)

Synonym(s):

BSA

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About This Item

Linear Formula:
CH3C[=NSi(CH3)3]OSi(CH3)3
CAS Number:
10416-59-8
Molecular Weight:
203.43
UNSPSC Code:
41116105
NACRES:
NA.22
PubChem Substance ID:
329750807
EC Number:
233-892-7
Beilstein/REAXYS Number:
1306669
MDL number:
MFCD00008270
Assay:
≥98.5% (GC)
Form:
liquid
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grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥98.5% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.417

bp

71-73 °C/35 mmHg (lit.)

density

0.832 g/mL at 20 °C (lit.)

SMILES string

C\C(O[Si](C)(C)C)=N/[Si](C)(C)C

InChI

1S/C8H21NOSi2/c1-8(9-11(2,3)4)10-12(5,6)7/h1-7H3/b9-8+

InChI key

SIOVKLKJSOKLIF-CMDGGOBGSA-N

General description

N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.

Application

Learn more in the Product Information
Suitable for the derivatization of 2-amino-2-dexoxyhexoses, ecdysones, hexosamines in glycosaminoglycans, 18-hydroxycorticosteroids, 15-Oxo-prostaglandin F2α, prostaglandins A,B and E and F, F2α, prostaglandins and metabolites, prostaglandins Emetabolites, sugar phosphates, steroids and testosterone.

Other Notes

Powerful silylating agent
Reagent for o-trimethylsilyl-aldono-1,4-lactones, trimethylsilyl and trimethylsilyl ether.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 3 - Skin Corr. 1B

supp_hazards

EUH014

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

111.2 °F - closed cup

flash_point_c

44 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG0589
BCCG0588
BCCF7229
BCCF0108
BCCD6803

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Related Content

Houben-Weyl Methods of Molecular Transformations. Heteroatom Analogues of Aldehydes and Ketones.
Aggarwal VK
Science of Synthesis Knowledge Updates, 27, 593-594 (2014)
J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
K. Blau et al.
Handbook of Derivatives for Chromatography (1993)
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Global Trade Item Number

SKUGTIN
15269-1ML04061837683350
15269-25ML04061838740489
15269-10X1ML04061837683343
15269-5ML04061837683367