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16033

1,2-Propanediol

Name: 1,2-Propanediol
Brand: SIAL

meets analytical specification of Ph. Eur., BP, USP, ≥99.5%

Synonym(s):

1,2-PDO, Propylene glycol

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About This Item

Linear Formula:

CH₃CH(OH)CH₂OH

CAS Number:

57-55-6

Molecular Weight:

76.09

UNSPSC Code:

12352100

NACRES:

NA.21

PubChem Substance ID:

57647543

EC Number:

200-338-0

Beilstein/REAXYS Number:

1340498

MDL number:

MFCD00064272

Assay:

≥99.5%

Form:

liquid

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Properties

vapor density

2.62 (vs air)

Quality Level

200

vapor pressure

0.08 mmHg ( 20 °C)

assay

≥99.5%

form

liquid

autoignition temp.

779 °F

quality

meets analytical specification of Ph. Eur., BP, USP

shelf life

24 mo.

expl. lim.

12.5 %

impurities

acidic reac. impurities, complies, organic volatile impurities, complies (GC), oxidizing substances, complies, reducing matter, complies, residual solvents, complies, ≤0.0005% heavy metals (as Pb), ≤0.002% free alkali (as NaOH), ≤0.003% free acid (as CH₃COOH), ≤0.2% water (Karl Fischer)

ign. residue

≤0.005% (as SO₄)

refractive index

n20/D 1.431-1.433, n20/D 1.432 (lit.)

bp

187 °C (lit.)

mp

−60 °C (lit.)

density

1.036 g/mL at 25 °C (lit.)

anion traces

chloride (Cl^-): ≤50 mg/kg, sulfate (SO₄^2-): ≤50 mg/kg

suitability

complies for appearance of solution

functional group

hydroxyl

SMILES string

CC(O)CO

InChI

1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3

InChI key

DNIAPMSPPWPWGF-UHFFFAOYSA-N

Description

General description

1,2-Propanediol is an 1,2-alkanediol. It can be obtained from glycerol, via hydrogenolysis in the presence of Ru/C and Amberlyst ion-exchange resins.

1,2-Propanediol is an important petrochemical that can be prepared by the hydrogenolysis of glycerol. It is mainly used as a cryoprotectant for biological samples and also as an additive in food, cosmetic and pharmaceutical industries.

Application

1,2-Propanediol may be employed as a cryoprotective agent for the preservation (by cooling to sub-zero temperatures) of human embryos and and oocytes (human and mouse).

Packaging

bottled under inert gas

Other Notes

The article number 16033-4X5L will be discontinued. Please order the single bottle 16033-5L which is physically identical with the same exact specifications.
The article number 16033-6X1L will be discontinued. Please order the single bottle 16033-1L which is physically identical with the same exact specifications.
The article number 16303-4X2.5L-R will be discontinued. Please order the single bottle 16303-2.5L-R which is physically identical with the same exact specifications.

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Storage Class

10 - Combustible liquids

flash_point_f

219.2 °F - closed cup

flash_point_c

104 °C - closed cup

ppe

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Aqueous phase hydrogenolysis of glycerol to 1, 2-propanediol without external hydrogen addition.

Roy D, et al.

Catalysis Today, 156(1), 31-37 (2010)

Cryopreservation of mouse and human oocytes using 1,2-propanediol and the configuration of the meiotic spindle.

D A Gook et al.

Human reproduction (Oxford, England), 8(7), 1101-1109 (1993-07-01)

Human and mouse oocytes were cryopreserved by a slow freeze, rapid thaw method, using propanediol (PROH) as the cryoprotectant. A simulated cryopreservation was also included in the study to detect the level of damage attributable to the PROH alone. Comparison

Glycerol hydrogenolysis to 1, 2-propanediol catalyzed by a heat-resistant ion-exchange resin combined with Ru/C.

Miyazawa T, et al.

Applied Catalysis A: General, 329, 30-35 (2007)

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Global Trade Item Number

SKU	GTIN
16033-30KG	04061838125163
16033-4X5L	04061838075871
16033-5L	04061838745422
16033-1L	04061838118219
16033-6X1L	04061838118226