17849
Enrofloxacin
≥99.0%
Synonym(s):
Baytril
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About This Item
Empirical Formula (Hill Notation):
C19H22FN3O3
CAS Number:
Molecular Weight:
359.39
UNSPSC Code:
41116105
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5307824
Quality Level
assay
≥99.0%, 99.0-101.0% (dried substance)
form
powder or crystals
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
SMILES string
CCN1CCN(CC1)c2cc3N(C=C(C(O)=O)C(=O)c3cc2F)C4CC4
InChI
1S/C19H22FN3O3/c1-2-21-5-7-22(8-6-21)17-10-16-13(9-15(17)20)18(24)14(19(25)26)11-23(16)12-3-4-12/h9-12H,2-8H2,1H3,(H,25,26)
InChI key
SPFYMRJSYKOXGV-UHFFFAOYSA-N
General description
Chemical structure: fluoroquinolone
Enrofloxacin is a veterinary fluoroquinolone (FQ) antibiotic with broad-spectrum antimicrobial activity. FQ drugs chelate to iron with high affinity. This chelation leads to inhibition of Fe(II)-dependent dioxygenases involved in the regulation of epigenetic control, collagen maturation, and HIF (hypoxia-inducible factor) degradation. The side effects associated with FQ drugs are renal toxicity and tendinopathy. Enrofloxacin is used in aquaculture and its use may cause an increase in the growth of antibiotic resistant microbes in an aquatic environment. The drug may have negative effects on public health and environment.
Application
Enrofloxacin has been used:
- to investigate the pathological mechanisms resulting from the toxicity of fluoroquinolones in mammalian cells
- to prepare a standard solution with 50% acetonitrile in a study to analyze illegal fish drugs used in aquaculture by employing surface-enhanced Raman spectroscopy (SERS)
- as an analyte in a chemiluminescence reagent system
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
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Yanina N Martínez et al.
Bioresource technology, 145, 280-284 (2013-04-06)
A keratinase isolated from Paecilomyces lilacinus (LPS #876) was tested against proteins present in the skin but the high enzyme activity was detected on collagen. Keratinase was physically immobilized onto PVA-pectin cryogels and enzyme release was 20.8±2.1%, 63.8±0.2%, 41.5±3.5% and
Jessica M Terry et al.
The Analyst, 136(5), 913-919 (2010-12-04)
Constructing flow-through reactors for chemiluminescence detection by machining channels into polymer disks has enabled the exploration of new configurations and materials that can improve signal intensity beyond that attainable with the traditional coiled-tubing design. Several approaches to merge reactant solutions
Sook Mei Khor et al.
Analytical and bioanalytical chemistry, 405(11), 3889-3898 (2013-02-27)
A displacement immunoassay involves having a labelled analogue of the analyte (the epitope) already bound to the antibody. The presence of the analyte causes a competition for antibodies, and some of the antibodies dissociates from the epitope so that it
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 17849-5G-F | 04061838753809 |
| 17849-25G-F | 04061838753793 |