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242845

Acetic anhydride

Name: Acetic anhydride
Brand: SIAL

ACS reagent grade, ≥98.0%, liquid

Synonym(s):

Acetanhydride, Acetic acid anhydride, Acetyl acetate, Acetyl anhydride, Ethanoic anhydride

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About This Item

Linear Formula:

(CH₃CO)₂O

CAS Number:

108-24-7

Molecular Weight:

102.09

NACRES:

NA.21

PubChem Substance ID:

24854587

UNSPSC Code:

12352100

EC Number:

203-564-8

MDL number:

MFCD00008705

Beilstein/REAXYS Number:

385737

Assay:

≥98.0%

Form:

liquid

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Properties

Product Name

Acetic anhydride, ACS reagent, ≥98.0%

grade

ACS reagent

Quality Level

200

vapor density

3.5 (vs air)

vapor pressure

10 mmHg ( 36 °C), 4 mmHg ( 20 °C)

assay

≥98.0%

form

liquid

autoignition temp.

629 °F

expl. lim.

10.3 %

impurities

MnO₄^- reducers, passes test

evapn. residue

≤0.003%

refractive index

n20/D 1.390 (lit.)

bp

138-140 °C (lit.)

mp

−73 °C (lit.)

solubility

H₂O: slightly soluble

density

1.08 g/mL (lit.)

anion traces

chloride (Cl^-): ≤5 ppm, phosphate (PO₄^3-): ≤0.001%, sulfate (SO₄^2-): ≤5 ppm

cation traces

Fe: ≤5 ppm, heavy metals: ≤2 ppm

functional group

anhydride, ester

SMILES string

CC(=O)OC(C)=O

InChI

1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3

InChI key

WFDIJRYMOXRFFG-UHFFFAOYSA-N

Description

General description

Acetic anhydride is an organic solvent. On dissolution in water it undergoes solvolysis to afford acetic acid. It is widely employed for the acetylation of various alcohols. Wacher process (starting reagent + a ketene) and Knapsack process (starting reagent = acetaldehyde) have been reported for the industrial preparation of acetic anhydride.

Application

Acetic anhydride has been used as one of the reaction components in the preparation of:

2-acetylamino-5-aminobenzenesulfonic acid
3,3′-bis(sulfonato)-4,4′-bis(chloroacetamido)azobenzene (BSBCA)
10-acetoxy-9-nitro-octadecanoic acid, allyl ester
9-nitro-oleic acid

It may be used for acetylation of anisole over HBEA zeolite in a batch reactor.

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pictograms

GHS02,GHS06,GHS05

signalword

Danger

hcodes

H226,H302,H314,H330

pcodes

P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

120.2 °F - closed cup

flash_point_c

49 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

易制毒化学品（2类）

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Nitrated fatty acids: synthesis and measurement.

Steven R Woodcock et al.

Free radical biology & medicine, 59, 14-26 (2012-12-04)

Nitrated fatty acids are the product of nitrogen dioxide reaction with unsaturated fatty acids. The discovery of peroxynitrite and peroxidase-induced nitration of biomolecules led to the initial reports of endogenous nitrated fatty acids. These species increase during ischemia/reperfusion, but concentrations

Synthesis of 3,3'-bis(sulfonato)-4,4'-bis(chloroacetamido)azobenzene and cysteine cross-linking for photo-control of protein conformation and activity.

Darcy C Burns et al.

Nature protocols, 2(2), 251-258 (2007-04-05)

This protocol describes a procedure for the synthesis of 3,3'-bis(sulfonato)-4,4'-bis(chloroacetamido)azobenzene (BSBCA), a water-soluble, thiol-reactive, photo-switchable cross-linker. In addition, a protocol is outlined for installing the cross-linker in an intramolecular fashion onto proteins bearing two surface-exposed Cys residues. BSBCA is designed

Acetylation of anisole by acetic anhydride over a HBEA zeolite-Origin of deactivation of the catalyst.

Rohan D, et al.

J. Catal., 177(2), 296-305 (1998)

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Global Trade Item Number

SKU	GTIN
242845-100G	04061825589589
242845-1KG	04061837886102
242845-3KG	04061825589596
242845-4X100G	04061825589602
242845-5G	04061825589619
242845-6X1KG	04061837886119