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Merck
CN

26454

Magnesium stearate

puriss., meets analytical specification of Ph. Eur., BP, ≥90% stearic and palmitic acid basis, ≥40% stearic acid basis (GC), 4.0-5.0% Mg basis (calc on dry sub.)

Synonym(s):

Stearic acid magnesium salt

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About This Item

Linear Formula:
[CH3(CH2)16CO2]2Mg
CAS Number:
Molecular Weight:
591.24
UNSPSC Code:
12352106
NACRES:
NA.22
PubChem Substance ID:
EC Number:
209-150-3
Beilstein/REAXYS Number:
3919702
MDL number:
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grade

puriss.

assay

≥40% stearic acid basis (GC), ≥90% stearic and palmitic acid basis, 4.0-5.0% Mg basis (calc on dry sub.)

quality

meets analytical specification of Ph. Eur., BP

impurities

acidity or alkalinity, complies, microbiological impurity, in accordance, residual solvents, complies

loss

≤6.0% loss on drying, 105 °C

mp

200 °C (lit.)

acid value

195‑210(fatty acid)

solubility

alcohol: insoluble, diethyl ether: insoluble, water: insoluble

anion traces

chloride (Cl-): ≤1000 mg/kg, sulfate (SO42-): ≤5000 mg/kg

cation traces

Cd: ≤3 mg/kg, Ni: ≤5 mg/kg, Pb: ≤10 mg/kg

suitability

in accordance for fatty acid composition, passes test for identity

application(s)

pharmaceutical (small molecule)

SMILES string

CCCCCCCCCCCCCCCCCC(=O)O[Mg]OC(=O)CCCCCCCCCCCCCCCCC

InChI

1S/2C18H36O2.Mg/c2*1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2*2-17H2,1H3,(H,19,20);/q;;+2/p-2

InChI key

HQKMJHAJHXVSDF-UHFFFAOYSA-L

Application

Magnesium stearate has been used as a tablet and capsule lubricant. It has also been used for preparing microcapsules.

Biochem/physiol Actions

Magnesium stearate is the magnesium salt of stearic acid that possess lubricating properties and hence prevents ingredients from sticking to manufacturing equipment during the compression of chemical powders into solid tablets. Dry coating of drugs with magnesium stearate leads to flow improvement, flow-aid and lubrication effects, tabletability as well as non-inhibited dissolution rate.


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Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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<BIG>Marleen de Veij</BIG>
Journal of Raman Spectroscopy, 40 (2008)
M J Amorim et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 39-44 (2001-07-05)
Several different peptides and proteins, such as the pancreatic trypsin inhibitor, growth factors and trefoil peptides, are known to play important roles in maintaining the structure and function of the gastrointestinal wall. With the advent of recombinant biotechnology, it has
Ziyaur Rahman et al.
International journal of pharmaceutics, 475(1-2), 462-470 (2014-09-01)
Clinical performance of an amorphous solid dispersion (ASD) drug product is related to the amorphous drug content because of the greater bioavailability of this form of the drug than its crystalline form. Therefore, it is paramount to monitor the amorphous