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Merck
CN

27285

Ethylenediaminetetraacetic acid disodium salt dihydrate

meets analytical specification of Ph. Eur., BP, USP, FCC, 99.0-101.0%

Synonym(s):

Disodium ethylenediaminetetraacetate dihydrate, EDTA disodium salt, EDTA-Na2, Edathamil, Edetate disodium salt dihydrate, Sequestrene Na2

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About This Item

Empirical Formula (Hill Notation):
C10H14N2Na2O8 · 2H2O
CAS Number:
Molecular Weight:
372.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352107
EC Number:
205-358-3
Beilstein/REAXYS Number:
3900609
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Quality Level

agency

tested according to BP, tested according to Ph. Eur., tested according to USP

reg. compliance

tested according to FCC

assay

99.0-101.0%

form

crystals

quality

meets analytical specification of Ph. Eur., BP, USP, FCC

reaction suitability

reagent type: chelator

impurities

residual solvents, complies, ≤0.001% cyanide (CN), ≤0.001% heavy metals (as Pb), ≤0.1% nitrilotriacetic acid (HPLC) (HPLC)

loss

8.7-11.4% loss on drying, 200 °C, 3 h

pH

4-5 (20 °C, 5%)

mp

248 °C (dec.) (lit.)

solubility

water: soluble 100 g/L at 20 °C

anion traces

chloride (Cl-): ≤100 mg/kg, sulfate (SO42-): ≤500 mg/kg

cation traces

As: ≤1 mg/kg, Ca:, in accordance, Fe: ≤10 mg/kg, Pb: ≤10 mg/kg

application(s)

pharmaceutical (small molecule)

SMILES string

O.O.O.O.[Na+].[Na+].[Na+].[Na+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.2Na.2H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;2*1H2/q;2*+1;;/p-2

InChI key

OVBJJZOQPCKUOR-UHFFFAOYSA-L

General description

Ethylenediaminetetraacetic acid disodium salt dihydrate, referred to as EDTA is a widely used chelator of divalent cations like Ca⁺². It can inhibit proteases dependent on metal ions, such as, calcium-dependent cysteine proteases. EDTA also acts as a chelator of the Zn ion, inhibiting metalloproteases that require zinc for activity.

Application

Ethylenediaminetetraacetic acid disodium salt dihydrate has been used along with Na2HPO4 and citric acid for preparing Na2EDTA-McIlvaine buffer. Aqueous solution of Ethylenediaminetetraacetic acid disodium salt dihydrate has also been used for photocatalytic hydrogen production
Chelator of divalent cations. Inhibits enzymes, such as metalloproteases, that require divalent cations for activity.

Other Notes

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hcodes

pictograms

Health hazardExclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Inhalation - STOT RE 2 Inhalation

target_organs

Respiratory Tract

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Articles

LC/LC-MS method identifies 8 aminoglycosides in pork using Discovery® DSC-18 SPE and Ascentis® Express C18 UHPLC, per Chinese standards.


Evaluation of EDTA as the chelator in the biuret reagent.
H Van Kley et al.
Clinical chemistry, 19(6), 621-623 (1973-06-01)
Haruthai Sangjarusvichai et al.
Talanta, 79(4), 1036-1041 (2009-07-21)
In this report, we aimed to extend our previous efforts toward the evaluation of sulfonamides (SAs) with a boron-doped diamond (BDD) electrode. We improved this method by reducing the analysis time using a monolithic column coupled with amperometric detection to
Sinan Akbayram et al.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(5), 494-496 (2010-06-10)
Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to antiplatelet antibodies that cause platelet clumping in blood anticoagulated with EDTA. The aggregation of platelets in EDTA-dependent PTCP is usually prevented by other anticoagulants



Global Trade Item Number

SKUGTIN
27285-500G-R04061826151648
27285-1KG-R04061826151631
27285-6X1KG-R04061835541164