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33429

Doxycycline hyclate

Name: Doxycycline hyclate
Brand: SIAL

VETRANAL^®, analytical standard

Synonym(s):

Doxycycline hydrochloride hemiethanolate hemihydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₄N₂O₈ · HCl · 0.5H₂O · 0.5C₂H₆O

CAS Number:

24390-14-5

Molecular Weight:

512.94

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329754541

MDL number:

MFCD07357237

Beilstein/REAXYS Number:

5702728

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Properties

grade

analytical standard

Quality Level

100

agency

EPA 1694

product line

VETRANAL^®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

solubility

DMSO: soluble 100 mM

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycoplasma, parasites

application(s)

clinical testing

format

neat

mode of action

protein synthesis | interferes

SMILES string

Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58

InChI

1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1

InChI key

HALQELOKLVRWRI-ZVACAFRPSA-N

Description

General description

Chemical structure: tetracycline

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Mode of Action: Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi.

Activity Spectrum: Effective against a broad spectrum inhibitor of matrix metalloproteinases in vivo.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H315,H319,H335,H361fd,H412

pcodes

P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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Borrelia miyamotoi infection presenting as human granulocytic anaplasmosis: a case report.

Hanumara Ram Chowdri et al.

Annals of internal medicine, 159(1), 21-27 (2013-07-03)

The diverse tickborne infections of the northeastern United States can present as undifferentiated flu-like illnesses. In areas endemic for Lyme and other tickborne diseases, patients presenting with acute febrile illness with myalgia, headache, neutropenia, thrombocytopenia, and elevated hepatic aminotransferase levels

Diagnosis and management of Q fever--United States, 2013: recommendations from CDC and the Q Fever Working Group.

Alicia Anderson et al.

MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 62(RR-03), 1-30 (2013-03-29)

Q fever, a zoonotic disease caused by the bacterium Coxiella burnetii, can cause acute or chronic illness in humans. Transmission occurs primarily through inhalation of aerosols from contaminated soil or animal waste. No licensed vaccine is available in the United

Doxycycline for stabilization of abdominal aortic aneurysms: a randomized trial.

C Arnoud Meijer et al.

Annals of internal medicine, 159(12), 815-823 (2014-02-04)

Doxycycline inhibits formation and progression of abdominal aortic aneurysms (AAAs) in preclinical models of the disease, but it is unclear whether and how this observation translates to humans. To test whether doxycycline inhibits AAA progression in humans. Randomized, placebo-controlled, double-blind

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Global Trade Item Number

SKU	GTIN
33429-100MG-R	04061835511433