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410225

Glycine

Name: Glycine
Brand: SIAL

ACS reagent grade, ≥98.5%, powder, crystals or granules

Synonym(s):

Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:

NH₂CH₂COOH

CAS Number:

56-40-6

Molecular Weight:

75.07

NACRES:

NA.21

PubChem Substance ID:

24865701

eCl@ss:

32160406

UNSPSC Code:

12352209

EC Number:

200-272-2

MDL number:

MFCD00008131

Beilstein/REAXYS Number:

635782

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Properties

Product Name

Glycine, ACS reagent, ≥98.5%

grade

ACS reagent

Quality Level

200

assay

≥98.5%

form

powder, crystals or granules

impurities

H₂SO₄, passes test (darkened), Hydrolyzable subsances, passes test

ign. residue

≤0.1%

color

white

pKa (25 °C)

(1) 2.35, (2) 9.60, 2.35

mp

240 °C (dec.) (lit.)

anion traces

chloride (Cl^-): ≤0.005%, sulfate (SO₄^2-): ≤0.005%

cation traces

NH₄⁺: ≤0.005%, heavy metals: ≤0.002% (by ICP)

application(s)

peptide synthesis

functional group

amine, carboxylic acid

SMILES string

NCC(O)=O

InChI

1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)

InChI key

DHMQDGOQFOQNFH-UHFFFAOYSA-N

Gene Information

rat ... Grin2a(24409)

Description

General description

Glycine is the simplest amino acid building block.

Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents. It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.

Biochem/physiol Actions

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View

Vinita Jagannath

Frontiers in Molecular Neuroscience (2017)

A Novel Acoustomicrofluidic Nebulization Technique Yielding New Crystallization Morphologies

Heba Ahmed

Advanced Materials, 30(3) (2018)

Amino acids: metabolism, functions, and nutrition

Guoyao Wu

Amino Acids, 37(1), 1-17 (2009)

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Global Trade Item Number

SKU	GTIN
410225-250G	04061835555116
410225-50G	04061835555123
410225-1KG	04065273586763