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52517

1,1,1,3,3,3-Hexafluoro-2-propanol

derivatization grade (GC derivatization), LiChropur™, ≥99.8%

Synonym(s):

HFP, Hexafluoroisopropanol

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About This Item

Linear Formula:
(CF3)2CHOH
CAS Number:
920-66-1
Molecular Weight:
168.04
UNSPSC Code:
12352104
NACRES:
NA.05
PubChem Substance ID:
329757847
EC Number:
213-059-4
Beilstein/REAXYS Number:
1841007
MDL number:
MFCD00011651
Assay:
≥99.8% (GC), ≥99.8%
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grade

derivatization grade (GC derivatization)

Quality Level

200

assay

≥99.8% (GC), ≥99.8%

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations, reagent type: derivatization reagent
reaction type: Esterifications

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.275 (lit.)

bp

59 °C (lit.)

mp

−4 °C (lit.)

density

1.596 g/mL at 25 °C (lit.)

SMILES string

OC(C(F)(F)F)C(F)(F)F

InChI

1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H

InChI key

BYEAHWXPCBROCE-UHFFFAOYSA-N

General description

Hexafluoroisopropanol (HFP) is generally used to denature the native state of proteins, and it also stabilizes the a-helical conformation in unfolded peptides and proteins like β-lactoglobulin and melittin.

Application

Suitable for the derivatization of glutamic acid, homovanillic, iso-homovanillic and dihydroxyphenyl acetic acids and Υ-aminobutyric acid.

Other Notes

Reagent for hexafluoroisopropyl ester, N-pentafluoropropionyl, and trifluoroacetyl..
Size-exclusion chromatography in 1,1,1,3,3,3-hexafluoro-2-propanol

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Health hazardCorrosion
GHS08,GHS05

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 2

flash_point_f

No data available

flash_point_c

No data available

ppe

Faceshields, Gloves, Goggles

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH0248
BCCG7310
BCCG5092
BCCG0003
BCCF7882

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Cooperative a-helix formation of ?-lactoglobulin and melittin induced by hexafluoroisopropanol
Hirota, Nami, Yuji Goto, and Kazuko Mizuno.
Protein Science, 6 (2), 416-421 (1997)
Thomas H Mourey et al.
Journal of chromatography. A, 964(1-2), 169-178 (2002-08-30)
1,1,1,3,3,3-Hexafluoroisopropanol is re-examined as an eluent for size-exclusion chromatography (SEC) of polyesters, nylons, and other polar polymers. It is shown that anomalous SEC behavior reported in previous literature can be eliminated by adding 0.01 M tetraethylammonium nitrate to the eluent.
Dave W Chen et al.
International journal of pharmaceutics, 430(1-2), 335-341 (2012-04-24)
This study investigated the in vitro release of vancomycin, gentamicin, and lidocaine from novel electrospun sandwich-structured polylactide-polyglycolide (PLGA)/collagen nanofibrous membranes. For the electrospinning of biodegradable membranes, PLGA/collagen and PLGA/vancomycin/gentamicin/lidocaine were separately dissolved in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). They were then electrospun into
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Global Trade Item Number

SKUGTIN
32053-250MG04061826701966
134708-100G04061835517794
134708-25G04061835554201
52517-10ML04061832550411
52517-1ML-KC04061838082978
52517-10X1ML04061838082961
52517-50ML04061832550428