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52619

Hexamethyldisilazane

Name: Hexamethyldisilazane
Brand: SIAL

derivatization grade (GC derivatization), LiChropur^™, ≥99.0% (GC)

Synonym(s):

HMDS

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About This Item

Linear Formula:

(CH₃)₃SiNHSi(CH₃)₃

CAS Number:

999-97-3

Molecular Weight:

161.39

UNSPSC Code:

12352200

NACRES:

NA.22

PubChem Substance ID:

329757861

EC Number:

213-668-5

Beilstein/REAXYS Number:

635752

MDL number:

MFCD00008259

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Properties

grade

derivatization grade (GC derivatization)

Quality Level

100

assay

≥99.0% (GC)

form

liquid

quality

LiChropur^™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.407 (lit.), n20/D 1.408

bp

125 °C (lit.)

SMILES string

C[Si](C)(C)N[Si](C)(C)C

InChI

1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

InChI key

FFUAGWLWBBFQJT-UHFFFAOYSA-N

Description

General description

Hexamethyldisilazane (HMDS) is a commercially available, silylating agent, which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.

Application

Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites, phenol, hydroquinone and catechol in urine samples, mixtures of free fatty acids and metal soaps in paint samples using gas chromatography/mass spectrometry (GC/MS).

Learn more in the Product Information

Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

Features and Benefits

HMDS is inexpensive and has a relatively low boiling point (124-127 °C).
It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.
The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.

Other Notes

Important silylating agent

Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS02,GHS06

signalword

Danger

hcodes

H225,H302 + H332,H311,H412

pcodes

P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

52.5 °F - closed cup

flash_point_c

11.4 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Articles

Silylation of Non-Steroidal Anti-Inflammatory Drugs

Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

Global Trade Item Number

SKU	GTIN
52619-10ML	04061832552521
52619-10X1ML	04061837683916
52619-1L	04061837683923
52619-1ML	04061832552545
52619-250ML	04061832555904
52619-50ML	04061832555911