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59924

Polysorbate 80

tested according to Ph. Eur.

Synonym(s):

TWEEN® 80, Polysorbatum 80, POE (20) sorbitan monooleate, Polyethylene glycol sorbitan monooleate, Polyoxyethylenesorbitan monooleate, Polysorbate 80

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About This Item

CAS Number:
9005-65-6
UNSPSC Code:
12161900
NACRES:
NA.21
MDL number:
MFCD00082107
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Quality Level

200

agency

tested according to Ph. Eur.

vapor pressure

<1 mmHg ( 20 °C)

description

non-ionic

form

liquid

mol wt

average mol wt 79,000

aggregation number

60

refractive index

n20/D 1.472 (lit.)

CMC

0.012

transition temp

cloud point 65 °C

density

1.064 g/mL at 25 °C (lit.)

HLB

15

application(s)

research use (small molecule)

SMILES string

CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO

InChI

1S/C32H60O10/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-30(36)40-25-24-37-27-29(39-22-19-34)32-28(38-21-18-33)26-31(42-32)41-23-20-35/h9-10,28-29,31-35H,2-8,11-27H2,1H3/b10-9+

InChI key

RGPBUVUVZKQNHD-MDZDMXLPSA-N

General description

Polysorbate 80 is a surfactant. Polysorbates are a combination of oleic esters of sorbitol and sorbitanes with polyethylene glycol chains.

Application

Polysorbate 80 has been used in drug (rapamycin) treatment and to study the effect of rapamycin on osteolysis and tumor growth. It has also been used in the preparation of spray-dried emulsions and to study antibacterial efficacy.

Biochem/physiol Actions

Polysorbates is used as emulsifiers, dissolving agents and stabilizer for essential oils, topical application and medical infusions including intravenous, subcutaneous or intramuscular administration.

Legal Information

TWEEN is a registered trademark of Croda International PLC

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK0465
BCCJ5727
BCCJ1250
BCCH8264
BCCH8263

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Enhancing the antibacterial efficacy of isoeugenol by emulsion encapsulation
Nielsen CK, et al.
International Journal of Food Microbiology, 229, 7-14 (2016)
Rapamycin inhibits osteolysis and improves survival in a model of experimental bone metastases
Hussein O, et al.
Cancer letters, 314(2), 176-184 (2012)
Osteolysis and pain due to experimental bone metastases are improved by treatment with rapamycin
Abdelaziz DM, et al.
Breast Cancer Research and Treatment, 143(2), 227-237 (2014)
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Global Trade Item Number

SKUGTIN
59924-100G-F04061832644714
59924-1KG-F04061832644721