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Merck
CN

71230

Thimerosal

97.0-101.0% (on dried substance, T)

Synonym(s):

2-(Ethylmercuriomercapto)benzoic acid sodium salt, Ethylmercurithiosalicylic acid sodium salt, Mercury-([o-carboxyphenyl]thio)ethyl sodium salt, Sodium ethylmercurithiosalicylate

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About This Item

Linear Formula:
2-(C2H5HgS)C6H4CO2Na
CAS Number:
Molecular Weight:
404.81
UNSPSC Code:
51473202
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-210-4
Beilstein/REAXYS Number:
8169555
MDL number:
Assay:
97.0-101.0% (on dried substance, T)
Form:
powder
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Quality Level

assay

97.0-101.0% (on dried substance, T)

form

powder

mp

234-237 °C (dec.) (lit.)

mode of action

enzyme | inhibits

SMILES string

[Na+].CC[Hg]Sc1ccccc1C([O-])=O

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

InChI key

RTKIYNMVFMVABJ-UHFFFAOYSA-L

Biochem/physiol Actions

Thimerosal is a sulfhydryl (thiol) oxidizing reagent capable of inhibiting a wide range of sulfhydryl-dependent enzymes and proteins such as PI3-kinase-dependent methionine synthase, glutamate transport receptors, and Na++K+ dependent ATPases.

Analysis Note

Solubility (EP/BP) Freely soluble in water, sparingly soluble or soluble in ethanol (96%), practically insoluble in ether and methylene cholride.

Other Notes

As part of the corporation global plan to support the Minamata Convention eliminating mercury-containing compounds, as of January 2021 customers will be required to provide an End-Use Declaration. Sales of thimerosal will be restricted for approved applications only.

Disclaimer

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.


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Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

target_organs

Kidney

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

危险化学品
非剧毒-急性毒性1

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Ildiko R Dunay et al.
Antimicrobial agents and chemotherapy, 48(12), 4848-4854 (2004-11-25)
Acute therapy with pyrimethamine plus sulfadiazine is the treatment of choice for reactivated toxoplasmic encephalitis (TE). Acute therapy is followed by lifelong maintenance therapy (secondary prophylaxis) with the same drugs at lower dosages. The use of pyrimethamine plus sulfadiazine is
John M Feller et al.
The Journal of clinical endocrinology and metabolism, 93(9), 3560-3567 (2008-06-12)
Hyperinsulinism with islet cell hyperplasia is a frequent complication, of unknown cause, in hemolytic disease of the newborn, occurring in Rh(D)-positive infants of Rh-isoimmunized Rh(D)-negative mothers, but not in infants with other hemolytic disorders. We investigated the possibility that trans-placentally
Pan-Chyr Yang et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 111(6), 333-339 (2012-07-04)
This study evaluated the immune response elicited by two formulations of an AS03(A)-adjuvanted H5N1 A/Indonesia/05/2005 prepandemic influenza vaccine, developed using manufacturing processes with or without thiomersal. In addition, it also evaluated compliance to the Centre for Biologics Evaluation and Research



Global Trade Item Number

SKUGTIN
71230-250G04061832404967
71230-10G04061835326174
71230-50G04061832404974