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76078

L-Methionine sulfoximine

Name: <SC>L</SC>-Methionine sulfoximine
Brand: SIAL

Synonym(s):

L-S-(3-Amino-3-carboxypropyl)-S-methylsulfoximine

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About This Item

Linear Formula:

CH₃S(O)(=NH)CH₂CH₂CH(NH₂)CO₂H

CAS Number:

15985-39-4

Molecular Weight:

180.23

UNSPSC Code:

12352200

Beilstein/REAXYS Number:

6175446

MDL number:

MFCD00002621

Form:

solid

Assay:

≥96% (rel., HPLC)

Biological source:

synthetic

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Properties

biological source

synthetic

Quality Level

500

assay

≥96% (rel., HPLC)

form

solid

optical activity

[α]20/D +10.8 to +14.0°, c = 1 in H₂O

concentration

95-102 % (w/w) (HPLC)

impurities

≤0.1% each single unknown impurity (rel.), ≤0.5% sulfated ash, ≤0.5% water (Karl Fischer), ≤1% methionine sulfone (rel.), ≤1% methionine sulfoxide (rel.), ≤10 mg/kg azide, ≤2% methionine (rel.), ≤5000 ppm ethanol (GC-HS)

mp

>210 °C (dec.) (lit.)

suitability

complies for H-NMR, complies for identity (HPLC)

SMILES string

CS(=N)(=O)CC[C@H](N)C(O)=O

InChI

1S/C5H12N2O3S/c1-11(7,10)3-2-4(6)5(8)9/h4,7H,2-3,6H2,1H3,(H,8,9)/t4-,11?/m0/s1

InChI key

SXTAYKAGBXMACB-DPVSGNNYSA-N

Description

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Protocols

LC/MS Analysis of L-Methionine Sulfoximine, Sulfone and Sulfoxide on Ascentis® Express HILIC

Separation of L-Methionine sulfone; L-Methionine sulfoximine; L-Methionine sulfoxide

LC/MS Analysis of L-Methionine Sulfoximine and Sulfone on Ascentis® Express OH5

LC/MS Analysis of L-Methionine Sulfoximine and Sulfone on Ascentis^® Express OH5

HIV-1 gp41 core with exposed membrane-proximal external region inducing broad HIV-1 neutralizing antibodies.

Ji Wang et al.

PloS one, 6(3), e18233-e18233 (2011-04-13)

The membrane-proximal external region (MPER) of the HIV-1 gp41 consists of epitopes for the broadly cross-neutralizing monoclonal antibodies 2F5 and 4E10. However, antigens containing the linear sequence of these epitopes are unable to elicit potent and broad neutralizing antibody responses

Binding thermodynamics of the N-terminal peptide of the CCR5 coreceptor to HIV-1 envelope glycoprotein gp120.

Evan T Brower et al.

Biochemistry, 48(4), 779-785 (2009-01-28)

The initial events of HIV-1 cell infection involve the sequential binding of the viral envelope glycoprotein gp120 to the cellular CD4 receptor and the coreceptor, usually CCR5 or CXCR4. Binding to the coreceptor triggers the chain of events that culminates

Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.

Hsiu-Ni Kung et al.

PLoS genetics, 7(8), e1002229-e1002229 (2011-08-20)

Although significant variations in the metabolic profiles exist among different cells, little is understood in terms of genetic regulations of such cell type-specific metabolic phenotypes and nutrient requirements. While many cancer cells depend on exogenous glutamine for survival to justify

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Global Trade Item Number

SKU	GTIN
76078-100G	04061832607689
76078-10G	04061832607696
76078-1G	04061826002469
76078-5G	04061832607702