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78445

Tetrahydrofuran

analytical standard

Synonym(s):

Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
109-99-9
Molecular Weight:
72.11
UNSPSC Code:
12191501
NACRES:
NA.24
PubChem Substance ID:
329768151
EC Number:
203-726-8
Beilstein/REAXYS Number:
102391
MDL number:
MFCD00005356
Technical Service
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grade

analytical standard

Quality Level

100

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

assay

≥99.9% (GC)

autoignition temp.

610 °F

shelf life

limited shelf life, expiry date on the label

contains

~0.025% 2,6-di-tert.-butyl-4-methylphenol as stabilizer

expl. lim.

1.8-11.8 %

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.407 (lit.)

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

solubility

H2O: soluble

density

0.889 g/mL at 25 °C (lit.)

application(s)

cleaning products
cosmetics
environmental
food and beverages
personal care

format

neat

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

General description

Tetrahydrofuran (THF) is a saturated cyclic ether. Its potential use as a biofuel for internal combustion engines is investigated.
Tetrahydrofuran is an important basic chemical compound, which belongs to the category of 5-membered heterocycles.
This substance is listed on the positive list of the EU regulation 10/2011 for plastics intended to come into contact with food. Find all available reference materials for compounds listed in 10/2011 here

Application

Tetrahydrofuran may find application as a solvent in the synthesis of (S)-2-(1-pyrrolidinylmethyl)pyrrolidine. It is also an excellent solvent for sodium diisopropylamide, which can find applications as an effective base for the isomerization of alkenes and metalation of 1,4-dienes.
Tetrahydrofuran may be used as an extraction solvent for the determination of pesticide residues in olive oil and phthalates in toys and child care articles by chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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signalword

Danger

target_organs

Central nervous system, Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF9908
BCCD0220
BCCB9673
BCBV4208
BCBT7857

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Articles

顶空级溶剂在有机挥发性杂质分析之中的应用

顶空级溶剂在有机挥发性杂质分析之中的应用

The Utility of Headspace Grade Solvents for the Analysis of Organic Volatile Impurities

Learn about analyzing organic volatile impurities (OVIs) in pharmaceuticals using SH-GC, focusing on suitable solvents and ensuring compliance.

Sodium Diisopropylamide in Tetrahydrofuran: Selectivities, Rates, and Mechanisms of Alkene Isomerizations and Diene Metalations
Algera FR, et al.
Journal of the American Chemical Society, 139(33), 11544-11549 (2017)
Hayashi T, et al. et al.
Asymmetric Synthesis: Graphical Abstracts and Experimental Methods (1998)
Direct Functionalization of Tetrahydrofuran and 1, 4-Dioxane: Nickel-Catalyzed Oxidative C (sp3) H Arylation
Liu D, et al.
Angewandte Chemie (International Edition in English), 52(16), 4453-4456 (2013)
View All Related Papers

Global Trade Item Number

SKUGTIN
78445-5ML-F04061832946580