92136
Genistein
analytical standard
Synonym(s):
4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
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About This Item
Empirical Formula (Hill Notation):
C15H10O5
CAS Number:
Molecular Weight:
270.24
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
EC Number:
207-174-9
Beilstein/REAXYS Number:
263823
MDL number:
grade
analytical standard
Quality Level
assay
≥97% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
food and beverages
format
neat
storage temp.
2-8°C
SMILES string
Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O
InChI
1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H
InChI key
TZBJGXHYKVUXJN-UHFFFAOYSA-N
General description
Genistein, a naturally occurring soy isoflavone, is a dietary protein tyrosine kinase (PTK) inhibitor. It is found to possess anticarcinogenic properties.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Inhibitor of tyrosine protein kinase; competitive inhibitor of ATP in other protein kinase reactions. Antiangiogenic agent, down-regulates the transcription of genes involved in controlling angiogenesis.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
This compound is commonly found in plants of the genus: glycyrrhiza
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Genistein inhibits renal cancer progression through long non-coding RNA HOTAIR suppression
Imai-Sumida M, et al.
Clinical Cancer Research, 3449-3449 (2017)
Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells
GP and SB
Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research, 7, 1345-1351 (1996)
Alexandra Mamagkaki et al.
PloS one, 16(4), e0250599-e0250599 (2021-04-28)
The objective of this study is to improve and optimize the formulation of Genistein in capsules in order to result in a better pharmacokinetic profile comparing to existing commercial products. In order to do this, five different formulations of Genistein
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 92136-10MG | 04061833269176 |