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About This Item
Empirical Formula (Hill Notation):
C12H15N3O2S
CAS Number:
Molecular Weight:
265.33
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
259-414-7
MDL number:
grade
analytical standard
Quality Level
assay
≥98%
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
CCCSc1ccc2[nH]c(NC(=O)OC)nc2c1
InChI
1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
InChI key
HXHWSAZORRCQMX-UHFFFAOYSA-N
General description
Albendazole is a benzimidazole derivative used for the treatment of human gastrointestinal helmintiasis. It inhibits microtubule and blocks the glucose uptake that causes depletion of glycogen stores and lowering formation of adinosine triphosphate (ATP) in the larval and adult stages of susceptible parasite.
Chemical structure: benzimidazole
Application
Albendazole may be used as a reference standard for the determination of albendazole and its major metabolites, albendazole sulphoxide and albendazole sulphone by high-performance liquid chromatography (HPLC) method in mice plasma.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Binds to tubulin and inhibits microtubule assembly.
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Oral
target_organs
Adrenal gland,Blood,male reproductive organs,spleen
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
农药列管产品
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Role of excipients in the crystallization of Albendazole.
Raval M K, et al.
Advanced Powder Technology, 26(4), 1102-1115 (2015)
Albendazole as a promising molecule for tumor control.
Castro L S E P W, et al.
Redox Biology, 10, 90-99 (2016)
Martin Spicher et al.
Antimicrobial agents and chemotherapy, 52(9), 3447-3450 (2008-07-16)
In vitro treatment of Echinococcus multilocularis and Echinococcus granulosus larval stages with the antimalarials dihydroartemisinin and artesunate (10 to 40 microM) exhibited promising results, while 6 weeks of in vivo treatment of mice infected with E. multilocularis metacestodes (200 mg/kg
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A4673-10G | 04061833374887 |

