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B1390

Bisacodyl

Name: Bisacodyl
Brand: SIAL

analytical standard, for drug analysis

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₁₉NO₄

CAS Number:

603-50-9

Molecular Weight:

361.39

NACRES:

NA.24

PubChem Substance ID:

329773183

UNSPSC Code:

41116107

EC Number:

210-044-4

MDL number:

MFCD00038039

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Properties

Quality Level

100

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

CC(=O)Oc1ccc(cc1)C(c2ccc(OC(C)=O)cc2)c3ccccn3

InChI

1S/C22H19NO4/c1-15(24)26-19-10-6-17(7-11-19)22(21-5-3-4-14-23-21)18-8-12-20(13-9-18)27-16(2)25/h3-14,22H,1-2H3

InChI key

KHOITXIGCFIULA-UHFFFAOYSA-N

Gene Information

human ... CHRM4(1132)

Description

General description

Bisacodyl is a diphenylmethane derivative, mainly used as a stimulant laxative for treating constipation.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

104K1274V

104K1274

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Internal anal sphincter relaxation associated with bisacodyl-induced colonic high amplitude propagating contractions in children with constipation: a colo-anal reflex?

L Rodriguez et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(11), 1023-e545-1023-e545 (2012-07-05)

Describe the association of internal anal sphincter (IAS) relaxation with colonic high- amplitude peristaltic contractions (HAPCs). Retrospective review of colon manometry tracings of children with constipation to determine the IAS relaxation characteristics associated with HAPC's (HAPC-IASR) events and compare them

Timing and frequency of bowel activity in patients ingesting sodium picosulphate/magnesium citrate and adjuvant bisacodyl for colon cleansing before colonoscopy.

Stephen Vanner et al.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 25(12), 663-666 (2011-12-17)

Despite the wealth of research investigating bowel cleansing efficacy, there are very little data on the timing or frequency of bowel movements after each agent is ingested. To examine the effect of each component of a three-day combined sodium picosulphate⁄magnesium

The concomitant use of an osmotic laxative, magnesium sulphate, and a stimulant laxative, bisacodyl, does not enhance the laxative effect.

Nobutomo Ikarashi et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 45(1-2), 73-78 (2011-11-17)

Patients with severe constipation are treated with combinations of several different laxatives. The purpose of this study is to examine whether the concomitant use of different laxatives enhances the laxative effect, using an osmotic laxative, magnesium sulphate (MgSO₄), and a

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Global Trade Item Number

SKU	GTIN
B1390-10G	04061833422250