B6506
Benzamidine hydrochloride hydrate
≥99%
Synonym(s):
Amidinobenzene hydrochloride, Benzamidinium chloride, Benzenecarboximidamide hydrochloride
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About This Item
Linear Formula:
C6H5C(=NH)NH2 · HCl · xH2O
CAS Number:
Molecular Weight:
156.61 (anhydrous basis)
UNSPSC Code:
12352107
NACRES:
NA.77
PubChem Substance ID:
EC Number:
216-795-4
Beilstein/REAXYS Number:
3594959
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥99%
form
powder
mp
86-88 °C (lit.)
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
storage temp.
2-8°C
SMILES string
Cl[H].[H]O[H].NC(=N)c1ccccc1
InChI
1S/C7H8N2.ClH.H2O/c8-7(9)6-4-2-1-3-5-6;;/h1-5H,(H3,8,9);1H;1H2
InChI key
BQVJCMMLDJPBFZ-UHFFFAOYSA-N
Application
Benzamidine hydrochloride hydrate has been used:
- in western blot analysis
- in immunoprecipitation
- in the purification of yeast dynein
- as a protease inhibitor in the preparation of brush-border membrane vesicles
- for the processing of human synovial fluid, blood and eye sleep
- to prevent non-specific degradation of cartilages
Biochem/physiol Actions
Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
Peptidase inhibitor.
Preparation Note
Benzamidine HCl is soluble in water and alcohol. Solubility testing in water at a concentration of 50 mg/ml yields a clear solution with heating. Benzamidine HCl is sensitive to oxidation. It is recommended to prepare solutions fresh each time in degassed water prior to use. However, frozen aliquots stored under inert gas, to exclude air, may be stable for a short time. Insufficient information is available to assess the shelf-life of a frozen solution.
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Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The MDM2 RING and central acidic domains play distinct roles in MDM2 homodimerization and MDM2-MDMX heterodimerization
Leslie PL, et al
The Journal of biological chemistry, 6(51), jbc-M115 (2015)
Combining Structure-Function and Single-Molecule Studies on Cytoplasmic Dynein
Single Molecule Analysis, 53-89 (2018)
Withaferin-A induces apoptosis in osteosarcoma U2OS cell line via generation of ROS and disruption of mitochondrial membrane potential
Zhang HL and Zhang H
Pharmacognosy magazine, 13(51), 523-523 (2017)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B6506-100G | 04061833434826 |
| B6506-25G | 04061833434857 |
| B6506-5G | 04061833434895 |