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BP227

Metformin hydrochloride

British Pharmacopoeia (BP) Reference Standard

Synonym(s):

1,1-Dimethylbiguanide hydrochloride, Metformin

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About This Item

Linear Formula:
NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
CAS Number:
Molecular Weight:
165.62
UNSPSC Code:
41116107
NACRES:
NA.24
EC Number:
214-230-6
MDL number:
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grade

pharmaceutical primary standard

API family

metformin

form

crystalline

shelf life

limited shelf life, expiry date on the label

manufacturer/tradename

BP

mp

223-226 °C (lit.)

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].CN(C)C(=N)NC(N)=N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChI key

OETHQSJEHLVLGH-UHFFFAOYSA-N

Gene Information

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Metformin hydrochloride BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Metformin Tablets
  • Metformin Oral Solution
  • Metformin and Sitagliptin Prolonged-release Tablets
  • Metformin Prolonged-release Tablets
  • Metformin and Sitagliptin Tablets
  • Biochem/physiol Actions

    Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.


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    pictograms

    Exclamation mark

    signalword

    Warning

    hcodes

    Hazard Classifications

    Acute Tox. 4 Oral - Eye Irrit. 2

    Storage Class

    11 - Combustible Solids

    wgk

    WGK 1

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable



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    Global Trade Item Number

    SKUGTIN
    BP22704061834363552