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C2180000

Cinnarizine

Name: Cinnarizine
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-trans-Cinnamyl-4-diphenylmethylpiperazine

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₂₈N₂

CAS Number:

298-57-7

Molecular Weight:

368.51

NACRES:

NA.24

PubChem Substance ID:

329774975

UNSPSC Code:

41116107

MDL number:

MFCD00056037

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Properties

grade

pharmaceutical primary standard

API family

cinnarizine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

C1CN(CCN1C\C=C\c2ccccc2)C(c3ccccc3)c4ccccc4

InChI

1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+

InChI key

DERZBLKQOCDDDZ-JLHYYAGUSA-N

Gene Information

human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779), HRH1(3269)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cinnarizine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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The effects of cinnarizine on menopausal symptoms in women.

P Y Cezarino et al.

Climacteric : the journal of the International Menopause Society, 14(4), 492-496 (2011-03-24)

To evaluate the effectiveness and safety of cinnarizine in the treatment of menopausal symptoms. A total of 100 climacteric and symptomatic women participated in a double-blind, placebo-controlled study. They were divided into two groups of the same size: Gcin, intake

Encapsulation of poorly soluble basic drugs into enteric microparticles: a novel approach to enhance their oral bioavailability.

Mohamed A Alhnan et al.

International journal of pharmaceutics, 416(1), 55-60 (2011-06-18)

Poorly water soluble basic drugs are very sensitive to pH changes and following dissolution in the acidic stomach environment tend to precipitate upon gastric emptying, which leads to compromised or erratic oral bioavailability. In this work, we show that the

Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation.

Anne T Larsen et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 339-350 (2012-11-28)

The in vivo performance of self-nanoemulsifying drug delivery systems (SNEDDSs) with different in vitro physicochemical properties were determined with the purpose of elucidating the parameters determining the in vivo performance of SNEDDSs. The in vitro characterisation included the use of

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Global Trade Item Number

SKU	GTIN
C2180000	04061833475300