D8255
1,4-Dithioerythritol
≥99.0%
Synonym(s):
erythro-1,4-Dimercapto-2,3-butanediol, erythro-2,3-Dihydroxy-1,4-butanedithiol, Cleland’s reagent, DTE
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About This Item
Linear Formula:
HSCH2CH(OH)CH(OH)CH2SH
CAS Number:
Molecular Weight:
154.25
UNSPSC Code:
12352201
NACRES:
NA.21
PubChem Substance ID:
EC Number:
229-998-8
Beilstein/REAXYS Number:
1719756
MDL number:
Quality Level
assay
≥99.0%
form
powder
reaction suitability
reagent type: reductant
pH
4.5-6.5 (25 °C, 15.4 g/L)
mp
82-84 °C (lit.)
storage temp.
2-8°C
SMILES string
O[C@@H](CS)[C@H](O)CS
InChI
1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+
InChI key
VHJLVAABSRFDPM-ZXZARUISSA-N
Application
Reagent for maintaining −SH groups in the reduced state; quantitatively reduces disulfides.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 3
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Christopher J Garland et al.
Science signaling, 10(486) (2017-07-06)
Vascular smooth muscle contraction is suppressed by feedback dilation mediated by the endothelium. In skeletal muscle arterioles, this feedback can be activated by Ca2+ signals passing from smooth muscle through gap junctions to endothelial cells, which protrude through holes in
Md A Hakim et al.
Journal of Alzheimer's disease reports, 5(1), 693-703 (2021-11-11)
As the sixth-leading cause of death in the United States, Alzheimer's disease (AD) entails deteriorating endothelial control of blood flow throughout the brain. In particular, reduced inward-rectifying K+ (KIR) channel function in animal models of aging and AD compromises endothelial
Vishal R Yadav et al.
American journal of physiology. Lung cellular and molecular physiology, 314(5), L724-L735 (2018-02-02)
Hypoxia-induced pulmonary vasoconstriction (HPV) is attributed to an increase in intracellular Ca2+ concentration ([Ca2+]i) in pulmonary artery smooth muscle cells (PASMCs). We have reported that phospholipase C-γ1 (PLCγ1) plays a significant role in the hypoxia-induced increase in [Ca2+]i in PASMCs
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D8255-5G | 04061833589311 |
| D8255-100G | 04061833589298 |
| D8255-10G | 04061833589304 |
| D8255-25G | 04061835544196 |