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F6377

Fluorescein sodium salt

Name: Fluorescein sodium salt
Brand: SIAL

Powder

Synonym(s):

Acid Yellow 73, D&C;Yellow No. 8, NaFl, NaFluo, Sodium fluorescein, Uranine

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₀Na₂O₅

CAS Number:

518-47-8

Molecular Weight:

376.27

UNSPSC Code:

12171500

NACRES:

NA.47

PubChem Substance ID:

24894907

EC Number:

208-253-0

MDL number:

MFCD00167039

Beilstein/REAXYS Number:

3833041

Colour Index Number:

45350

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Properties

Product Name

Fluorescein sodium salt, used as fluorescent tracer

Quality Level

200

form

powder

technique(s)

titration: suitable

pH

8.3 (20 °C, 10 g/L)

mp

>300 °C

solubility

H₂O: 1 mg/mL

density

0.78 g/cm³ at 29.6 °C (85.3 °F at 699.7 hPa)

fluorescence

λ_ex 460 nm; λ_em 515 nm(lit.)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].[Na+].[O-]c1ccc2c(Oc3cc([O-])ccc3C24OC(=O)c5ccccc45)c1

InChI

1S/C20H12O5.2Na/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20;;/h1-10,21-22H;;/q;2*+1/p-2

InChI key

RGPLGPBQJOQFJS-UHFFFAOYSA-L

Description

General description

Fluorescein is a xanthene dye and is a common labeling agent in biology.

Application

Fluorescein sodium salt has been used as a solute to study microvessel permeability. It has been used as a test molecule to study blood barrier penetration.

Water soluble fluorescent dye used in permeability and vascular perfusion studies due to its small molecular radius. Sodium fluorescein is used as a fluorescent tracer to study blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) permeability in rodent models. The dye was used as a probe substrate in the study of organic anion transporting polypeptide (OATP) mediated drug transport in hepatocytes. Sodium fluorescein was also used to monitor in situ solute transportation into bone through fluorescence recovery after photobleaching (FRAP).

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

423.7 °F - Pensky-Martens closed cup

flash_point_c

217.6 °C - Pensky-Martens closed cup

ppe

Eyeshields, Gloves, type N95 (US)

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Temperature dependence of electronic parameters of organic Schottky diode based on fluorescein sodium salt.

Yahia IS, et al.

Synthetic Metals, 161(9), 881-887 (2011)

Involvement of central histaminergic and cholinergic systems in the morphine-induced increase in blood-brain barrier permeability to sodium fluorescein in mice.

R Oishi et al.

Naunyn-Schmiedeberg's archives of pharmacology, 339(1-2), 159-165 (1989-01-01)

Morphine (5 mg/kg, s.c.) caused a submaximal increase in the brain level of sodium fluorescein administered i.v. Histamine H1-antagonists, diphenhydramine and mepyramine, given either i.p. or i.c.v., had no significant influence on the effect of morphine. H2-Antagonists, cimetidine and ranitidine

In vitro model of the outer blood-retina barrier.

Steuer H

Brain Research. Brain Research Protocols, 13, 26-26 (2004)

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Global Trade Item Number

SKU	GTIN
F6377-100G	04061835347667
F6377-500G	04061833618615