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H2910

Hydrochlorothiazide

Name: Hydrochlorothiazide
Brand: SIAL

meets USP testing specifications

Synonym(s):

6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):

C₇H₈ClN₃O₄S₂

CAS Number:

58-93-5

Molecular Weight:

297.74

NACRES:

NA.21

PubChem Substance ID:

24895542

UNSPSC Code:

12352125

EC Number:

200-403-3

MDL number:

MFCD00051765

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Properties

Quality Level

200

agency

USP/NF, meets USP testing specifications

form

solid

application(s)

pharmaceutical (small molecule)

SMILES string

NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl

InChI

1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

InChI key

JZUFKLXOESDKRF-UHFFFAOYSA-N

Gene Information

human ... ALB(213), CA1(759), CA2(760), CA4(762), SLC12A3(6559)

Description

Biochem/physiol Actions

Carbonic anhydrase inhibitor

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pictograms

GHS08

signalword

Warning

hcodes

H351

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

监管及禁止进口产品

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Aggravation by propranolol of hyperglycaemic effect of hydrochlorothiazide in type II diabetics without alteration of insulin secretion.

A Dornhorst et al.

Lancet (London, England), 1(8421), 123-126 (1985-01-19)

14 hypertensive men with type II diabetes sequentially received, in random order, hydrochlorothiazide 50 mg twice a day, propranolol 80 mg twice a day, and both drugs in combination. The 3-week treatment periods were separated by a 1-week washout period.

Differential effects of renin-angiotensin-aldosterone system inhibition, sympathoinhibition and diuretic therapy on endothelial function and blood pressure in obesity-related hypertension: a double-blind, placebo-controlled cross-over trial.

Johannes A N Dorresteijn et al.

Journal of hypertension, 31(2), 393-403 (2012-12-14)

The objective of this study is to determine the effects of renin-angiotensin-aldosterone system inhibition, sympathoinhibition and diuretic therapy on endothelial function and blood pressure in obesity-related hypertension. A randomized, four-way, double-blind, crossover study in 31 adults with previously untreated obesity-related

Half a century of hydrochlorothiazide: facts, fads, fiction, and follies.

Franz H Messerli et al.

The American journal of medicine, 124(10), 896-899 (2011-10-04)

Hydrochlorothiazide (HCTZ) has become by far the most commonly prescribed antihypertensive drug in the US. In 2008, 47.8 million prescriptions were written for HCTZ alone and 87.1 million prescriptions for HCTZ combinations. However, there is no evidence that HCTZ in

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Global Trade Item Number

SKU	GTIN
H2910-25G	04061833611289
H2910-5G	04061833792490