M4125
D-Mannitol
≥98% (GC)
Synonym(s):
Mannite
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About This Item
Empirical Formula (Hill Notation):
C6H14O6
CAS Number:
Molecular Weight:
182.17
UNSPSC Code:
12352201
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-711-8
Beilstein/REAXYS Number:
1721898
MDL number:
biological source
plant
Quality Level
assay
≥98% (GC)
form
powder
color
white
useful pH range
5.0-6.5 (25 °C, 182 g/L, (77 °F ))
mp
167-170 °C (lit.)
solubility
water: 100 mg/mL, clear, colorless
storage temp.
room temp
SMILES string
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
InChI
1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1
InChI key
FBPFZTCFMRRESA-KVTDHHQDSA-N
General description
D-Mannitol, a naturally occurring six-carbon sugar alcohol or polyol, is found in plants such as algae, onions, grasses, and olives. It is considered safe due to its relatively lower glycemic index than sucrose.
Application
D-Mannitol has been used:
- in osmotic loading to adjust the osmolarity of solutions
- as a component of test sugar solution for cellobiose-mannitol permeability test
- as an internal standard in nuclear magnetic resonance (NMR) to compare/analyze the mannitol concentrations in urine samples
- to treat the control cells and regulate the osmotic pressure of high glucose
D-mannitol has been used as a hydroxyl radical scavenger and as a medium supplement.
Biochem/physiol Actions
A sugar alcohol sweet tastant. Used in sweetness inhibition studies.
D-Mannitol may play an important role in lipolysis and fat oxidation as it can enhance the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase 1 (ACC). It serves as an anti-obesity supplement. D-Mannitol stimulates the synthesis of short-chain fatty acids (SCFAs), which regulate lipid metabolism in the liver.
Other Notes
To gain a comprehensive understanding of our extensive range of Sugar alcohols for your research, we encourage you to visit our Carbohydrates Category page.
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Storage Class
11 - Combustible Solids
ppe
Eyeshields, Gloves, type N95 (US)
flash_point_f
Not applicable
flash_point_c
Not applicable
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S J Upton et al.
Journal of clinical microbiology, 33(2), 371-375 (1995-02-01)
Surface-sterilized oocysts of Cryptosporidium parvum were applied to subconfluent monolayers of human adenocarcinoma (HCT-8) cells grown on coverslips in six-well cluster plates. Parasite-infected cultures were then incubated in RPMI 1640 with 10% fetal bovine serum, 15 mM HEPES (N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid)
A Matsuzaki et al.
Cancer research, 49(20), 5702-5707 (1989-10-15)
Rat 3Y1 fibroblasts transformed by the E1A gene of adenovirus type 12 (E1A-3Y1 cells) are highly sensitive to the cell-killing effect of 1,3-dilinoleoylglycerol (DLG) administered in a culture medium, whereas the parental 3Y1 cells are less sensitive (H. Shimura et
Tomoyuki Yamaguchi et al.
Scientific reports, 8(1), 15289-15289 (2018-10-18)
To study development of the conceptus in xenogeneic environments, we assessed interspecies chimera formation as well as tetraploid complementation between mouse and rat. Overall contribution of donor PSC-derived cells was lower in interspecies chimeras than in intraspecies chimeras, and high
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M4125-10MG | 04061835546770 |
| M4125-5KG | 04061835546800 |
| M4125-100G | 04061835546763 |
| M4125-1KG | 04061835546787 |
| M4125-500G | 04061835546794 |