N0392
Nordoxepin hydrochloride
analytical standard, ≥98.0% (TLC), powder
Synonym(s):
11(6H)-(3-[Methylamino]propylidene)dibenz[b,e]oxepine
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About This Item
Empirical Formula (Hill Notation):
C18H19NO · HCl
CAS Number:
Molecular Weight:
301.81
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
grade
analytical standard
Quality Level
assay
≥98.0% (TLC)
form
powder
technique(s)
HPLC: suitable
color
white to yellow
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
Cl.CNCC\C=C1/c2ccccc2COc3ccccc13
InChI
1S/C18H19NO.ClH/c1-19-12-6-10-16-15-8-3-2-7-14(15)13-20-18-11-5-4-9-17(16)18;/h2-5,7-11,19H,6,12-13H2,1H3;1H/b16-10+;
InChI key
GNPPEZGJRSOKRE-QFHYWFJHSA-N
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Doxepin metabolite.
Features and Benefits
Shelf-life of the powder is at least 10 years.
Other Notes
Mixture of cis- and trans-isomers
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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C W Harrell et al.
Electrophoresis, 19(5), 712-718 (1998-06-18)
The separation of seven structurally similar antidepressant drugs (amitriptyline, nortriptyline, imipramine, desipramine, protriptyline, doxepin, and nordoxepin) was achieved in under 15 min using a novel nonionic micelle polymer, poly(n-undecyl-alpha-D-glucopyranoside) (PUG) by use of capillary zone electrophoresis (CZE). Systematic studies with
Antonia Gronewold et al.
Forensic science international, 190(1-3), 74-79 (2009-06-16)
Body fluids and tissues in eight doxepin (Dox)-related deaths were investigated in order to prove whether the individual concentration of Dox, the concentration sum of parent drug and its active metabolite N-desmethyldoxepin (NDox) or the concentration ratio Dox/Ndox valuably contribute
Robert Schomburg et al.
Journal of neural transmission (Vienna, Austria : 1996), 118(4), 641-645 (2011-02-26)
Doxepin--like other antidepressant drugs (ADs)--shows a variable antidepressant effect in clinical practice. The cause for this variability is as yet unclear; however, pharmacokinetic factors such as the variable permeability of doxepin into the cerebrospinal fluid (CSF), may contribute to the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N0392-25MG | 04061832850924 |