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N8280

Naproxen

Name: Naproxen
Brand: SIAL

meets USP testing specifications

Synonym(s):

(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid, (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid

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About This Item

Linear Formula:

CH₃OC₁₀H₆CH(CH₃)CO₂H

CAS Number:

22204-53-1

Molecular Weight:

230.26

UNSPSC Code:

12352200

NACRES:

NA.21

PubChem Substance ID:

24897861

EC Number:

244-838-7

Beilstein/REAXYS Number:

3591068

MDL number:

MFCD00010500

Form:

powder

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Properties

agency

USP/NF, meets USP testing specifications

form

powder

mp

152-154 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O

InChI

1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1

InChI key

CMWTZPSULFXXJA-VIFPVBQESA-N

Gene Information

human ... MAPK14(1432), PTGS1(5742), PTGS2(5743)
rat ... Alox5(25290), Ptgs1(24693)

Description

Biochem/physiol Actions

Non-selective cyclooxygenase (COX-1 and COX-2) inhibitor.

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pictograms

GHS08,GHS07,GHS09

signalword

Warning

hcodes

H302,H315,H319,H335,H361fd,H411

pcodes

P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

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Renal effects of selective cyclooxygenase-2 inhibition in normotensive salt-depleted subjects.

J Rossat et al.

Clinical pharmacology and therapeutics, 66(1), 76-84 (1999-08-03)

To compare the renal hemodynamic and tubular effects of celecoxib, a selective inhibitor of cyclooxygenase-2 (COX-2) to those of naproxen, a nonselective inhibitor of cyclooxygenases in salt-depleted subjects. Forty subjects were randomized into four parallel groups to receive 200 mg

A hydrogen sulfide-releasing cyclooxygenase inhibitor markedly accelerates recovery from experimental spinal cord injury.

Michela Campolo et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(11), 4489-4499 (2013-08-01)

Spinal cord trauma causes loss of motor function that is in part due to the ensuing inflammatory response. Hydrogen sulfide (H2S) is a potent, endogenous anti-inflammatory and neuroprotective substance that has been explored for use in the design of novel

Separation of (R)- and (S)-naproxen using micellar chromatography and an alpha 1-acid-glycoprotein column: application for chiral monitoring in human liver microsomes by coupled-column chromatography.

D Haupt et al.

Journal of biochemical and biophysical methods, 25(4), 273-284 (1992-12-01)

A column-switching system for fast determination of (R)- and (S)-naproxen in liver microsomes has been developed. The centrifuged sample was injected directly onto a pre-column with octadecylcoated silica. The retained analytes were then directed to an alpha 1-AGP column using

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Global Trade Item Number

SKU	GTIN
N8280-5G	04061834118497