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N9890

Norfloxacin

analytical standard, ≥98% (TLC)

Synonym(s):

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-piperazino-3-quinolinecarboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C16H18FN3O3
CAS Number:
70458-96-7
Molecular Weight:
319.33
NACRES:
NA.24
PubChem Substance ID:
329818696
UNSPSC Code:
41116107
EC Number:
274-614-4
MDL number:
MFCD00079532
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grade

analytical standard

Quality Level

200

agency

EPA 1694

assay

≥98% (TLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

storage temp.

2-8°C

SMILES string

CCN1C=C(C(O)=O)C(=O)c2cc(F)c(cc12)N3CCNCC3

InChI

1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)

InChI key

OGJPXUAPXNRGGI-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)
rat ... Gabra1(29705)

General description

Norfloxacin is a broad spectrum antibiotic, which is used against a wide variety of gram positive and gram negative bacteria.
Chemical structure: fluoroquinolone

Application

Norfloxacin may be used as a standard in the determination of norfloxacin in human serum samples using fluorometric spectrophotometry.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Norfloxacin blocks DNA replication by interfering with an ATP-induced structural transition of DNA complexed with DNA gyrase (topoisomerase).
Mode of action: inhibits bacterial DNA replication
Antimicrobial spectrum: Gram-negative bacteria; less effective against Gram-positive bacteria

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCL9335
SLCG1651
SLCD0585
SLBZ1549
SLBX1642

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Articles

抗生素对核酸合成的抑制作用

喹诺酮类药物是一类重要的抗生素，它们通过抑制拓扑异构酶来干扰DNA合成，最常见的是拓扑异构酶II（DNA旋转酶），它是一种参与DNA复制的酶。

Inhibition of Nucleic Acid Synthesis by Antibiotics

Explore how antibiotics, particularly quinolones, inhibit nucleic acid synthesis by targeting topoisomerases, crucial for DNA replication processes.

Fluorescence reaction and complexation equilibria between norfloxacin and aluminium (III) ion in chloride medium
Djurdjevic.TP, et al.
Analytica Chimica Acta, 300, 253-259 (1995)
L M Cavaco et al.
Journal of clinical microbiology, 47(9), 2751-2758 (2009-07-03)
Fluoroquinolone resistance in members of the Enterobacteriaceae family is mostly due to mutations in the quinolone resistance-determining regions of the topoisomerase genes. However, transferable genes encoding quinolone resistance have recently been described. The current methods for susceptibility testing are not
Deepika Sharma et al.
European journal of medicinal chemistry, 44(6), 2347-2353 (2008-10-15)
In the present study, we have synthesized 2-(substituted phenyl)-1H-imidazole (1-12) and (substituted phenyl)-[2-(substituted phenyl)-imidazol-1-yl]-methanone (13-26) analogues and screened them for their antimicrobial activity against gram positive, gram negative and fungal species. The results of antibacterial study indicated that compounds 15
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Global Trade Item Number

SKUGTIN
N9890-1G04061835506538
N9890-5G04061835516216