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P1004

Polymyxin B sulfate salt

Name: Polymyxin B sulfate salt
Brand: SIAL

Synonym(s):

Polymixin, Polymixin B, Polymixin B sulfate

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About This Item

Empirical Formula (Hill Notation):

C₅₅H₉₆N₁₆O₁₃ · 2H₂SO₄

CAS Number:

1405-20-5

Molecular Weight:

1385.61

UNSPSC Code:

51283106

NACRES:

NA.76

EC Number:

215-774-7

MDL number:

MFCD00131991

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Properties

biological source

Pseudomonas aeruginosa

Quality Level

200

form

powder

storage condition

(Tightly closed. Dry. )

solubility

water: 50 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, fungi

mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

Description

General description

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate.

Application

Polymyxin B sulfate salt has been used:

in human aortic endothelial cells (HAEC) cell culture to exclude potential endotoxin contamination in recombinant adiponectin
in the analysis of the isolates
in endotoxin-neutralizing activity of α-amylase (AmyI-1)-18 (LAL assay)

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa†. It also has uses studying multidrug-resistant pathogens††, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

Biochem/physiol Actions

Polymyxin B is one of the most important antibiotics used to treat gram-negative bacterial infections, including infections caused by carbapenem-resistant non-fermenters and carbapenem-resistant Enterobacteriaceae.

Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.

Features and Benefits

High quality antibiotic suitable for mulitple research applications

Preparation Note

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions.

Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.

Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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Biochemical and toxic diversity of Bacillus cereus in a pasta and meat dish associated with a food-poisoning case

Pirhonen T I, et al.

Food Microbiology, 22(1), 87-91 (2005)

Dosing and pharmacokinetics of polymyxin B in patients with renal insufficiency

Thamlikitkul V, et al.

Antimicrobial Agents and Chemotherapy, e01337-e01316 (2017)

Globular adiponectin counteracts VCAM-1-mediated monocyte adhesion via AdipoR1/NF-kappaB/COX-2 signaling in human aortic endothelial cells

Addabbo F, et al.

American Journal of Physiology. Endocrinology and Metabolism, 301(6), E1143-E1143 (2011)

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Global Trade Item Number

SKU	GTIN
P1004-25MU	04061835547296
P1004-5MU	04061835547302
P1004-10MU	04061835547272
P1004-1MU	04061835547289
P1004-50MU	04061834353638