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P4722

Pyridoxine hydrochloride

Name: Pyridoxine hydrochloride
Brand: SIAL

meets USP testing specifications

Synonym(s):

Adermine hydrochloride, PN HCl, Pyridoxol hydrochloride, Vitamin B₆ hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₁NO₃ · HCl

CAS Number:

58-56-0

Molecular Weight:

205.64

NACRES:

NA.21

PubChem Substance ID:

24898493

eCl@ss:

34058008

UNSPSC Code:

12352205

EC Number:

200-386-2

MDL number:

MFCD00012807

Beilstein/REAXYS Number:

3632435

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Properties

biological source

synthetic (organic)

Quality Level

200

agency

USP/NF, meets USP testing specifications

assay

98.0-102.0% dry basis

form

powder

color

white

mp

214-215 °C (lit.)

application(s)

pharmaceutical (small molecule)

SMILES string

Cl[H].Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

InChI key

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

Description

General description

Vitamin B group is water-soluble and exists in six forms namely the pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. The food sources of vitamin B₆include grains, nuts, fruits, vegetables and meat.

Application

Pyridoxine hydrochloride has been used to test its neuroprotective functionality in traumatic brain injury (TBI) rats. It has also been used as a reference standard to quantify vitamin B₆ in feed and digesta samples using high-performance liquid chromatography(HPLC).

Biochem/physiol Actions

Pyridoxine plays a key role in metabolism both carbohydrates and amino acids. It supports brain development and its deficiency levels may lead to depletion of γ-aminobutyric acid (GABA) levels. Pyridoxine catalyzes the neurotransmitter biosynthesis like dopamine and serotonin. Pyridoxine in excess or deficient may lead to neuropathy.

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pictograms

GHS05

signalword

Danger

hcodes

H318

pcodes

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Articles

细胞培养中的维生素B6、吡哆醛和吡哆醇

该页面针对维生素B6、吡哆醛和吡哆醇如何影响无血清、无蛋白细胞培养系统（用于包括单克隆抗体在内的异源蛋白的生物制造）的性能提供了全面的分析。本页介绍吡哆醛、吡哆醇的体外化学和生物化学。

Vitamin B6, Pyridoxal and Pyridoxine in Cell Culture

Vitamin B6's impact on serum-free cell culture systems is explored for protein manufacturing.

B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin

Calderon-Ospina CA, et al.

CNS Neuroscience & Therapeutics (2019)

Pyridoxine administration improves behavioral and anatomical outcome after unilateral contusion injury in the rat

Kuypers NJ and Hoane MR

Journal of Neurotrauma, 27(7), 1275-1282 (2010)

Nutritional neuropathies

Hammond N, et al.

Neurologic Clinics, 31(2), 477-477 (2013)

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Global Trade Item Number

SKU	GTIN
P4722-10G	04061834375142
P4722-100G	04061834375135