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PHR1233

Biotin

Name: Biotin
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

D-Biotin, Bios II, Coenzyme R, Vitamin B7, Vitamin H

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₆N₂O₃S

CAS Number:

58-85-5

Molecular Weight:

244.31

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329823238

EC Number:

200-399-3

Beilstein/REAXYS Number:

86838

MDL number:

MFCD00005541

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. B1116000, traceable to USP 1071508

API family

biotin

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

231-233 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2

InChI

1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1

InChI key

YBJHBAHKTGYVGT-ZKWXMUAHSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biotin is a water-soluble vitamin, essential for amino acids and carbohydrates metabolism. It is involved in de novo synthesis of purine nucleotides and plays a role in gene expression and DNA replication.

Application

Biotin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical preparations using a bio-sensing system and chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC0265 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Using of HPLC coupled with coulometric detector for the determination of biotin in pharmaceuticals.

Zerzanova A, et al.

Journal of Pharmaceutical and Biomedical Analysis, 45(5), 730-735 (2007)

Determination of biotin in foodstuffs and pharmaceutical preparations using a biosensing system based on the streptavidin--biotin interaction.

Reyes FD, et al.

Analytica Chimica Acta, 436(1), 109-117 (2001)

Liquid chromatographic determination of biotin in multivitamin-multimineral tablets.

Ekpe AE and Hazen C

Journal of Pharmaceutical and Biomedical Analysis, 16(8), 1311-1315 (1998)

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Global Trade Item Number

SKU	GTIN
PHR1233-1G	04061835237715