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PHR1272

Maleic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

cis-Butenedioic acid, Toxilic acid

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About This Item

Linear Formula:
HO2CCH=CHCO2H
CAS Number:
110-16-7
Molecular Weight:
116.07
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823268
EC Number:
203-742-5
Beilstein/REAXYS Number:
605762
MDL number:
MFCD00063177
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. M01000000, traceable to USP 1374500

API family

maleic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

130-135 °C (lit.)

density

1.59 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

OC(=O)\C=C/C(O)=O

InChI

1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-

InChI key

VZCYOOQTPOCHFL-UPHRSURJSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Maleic acid may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by a spectrophotometry technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA0008 in the slot below. This is an example certificate only and may not be the lot that you receive.

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pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

target_organs

Respiratory system

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Spectrophotometric determination of ascorbic acid in pharmaceuticals by background correction and flow injection
Verma KK, et al.
Analyst, 116(6), 641-645 (1991)
Ela Lutwak et al.
Reproduction (Cambridge, England), 148(5), 507-517 (2014-08-15)
Similar expression to FGF (Sef or IL17-RD), is a tumor suppressor and an inhibitor of growth factors as well as of pro-inflammatory cytokine signaling. In this study, we examined the regulation of Sef expression by gonadotropins during ovarian folliculogenesis. In
Jianbin Zhang et al.
AAPS PharmSciTech, 15(3), 731-740 (2014-02-21)
The objective of this study is to investigate the effect of lipolysis on the release of poorly water-soluble drug from SMEDDS in the perspective of drug core/shell location. For this purpose, four SMEDDS formulations with various core/shell properties were developed
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Global Trade Item Number

SKUGTIN
PHR1272-500MG04061835233366