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PHR1549

1,4-Dioxane

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

1,4-Dioxane, Diethylene oxide, Dioxane

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About This Item

Empirical Formula (Hill Notation):
C4H8O2
CAS Number:
123-91-1
Molecular Weight:
88.11
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823458
EC Number:
204-661-8
Beilstein/REAXYS Number:
102551
MDL number:
MFCD00006571
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1601521

vapor density

3 (vs air)

vapor pressure

27 mmHg ( 20 °C), 40 mmHg ( 25 °C)

CofA

current certificate can be downloaded

autoignition temp.

356 °F

expl. lim.

22 %

packaging

ampule of 3x1.2 mL each

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

refractive index

n20/D 1.422 (lit.)

bp

100-102 °C (lit.)

mp

10-12 °C (lit.)

density

1.034 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

C1COCCO1

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

InChI key

RYHBNJHYFVUHQT-UHFFFAOYSA-N

General description

1,4-Dioxane belongs to the class of volatile organic compounds (VOCs).
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)

Application

1,4-Dioxane may be used as a pharmaceutical reference standard for the determination of the analyte in bulk pharmaceuticals, and cosmetic raw materials and finished products by chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0289 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Danger

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Respiratory system

supp_hazards

EUH019,EUH066

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

51.8 °F - closed cup

flash_point_c

11 °C - closed cup

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Occurrence of 1, 4-dioxane in cosmetic raw materials and finished cosmetic products
Black RE, et al.
Journal of AOAC (Association of Official Analytical Chemists) International, 84(3), 666-670 (2001)
A capillary gas chromatographic procedure for the analysis of nine common residual solvents in water-insoluble bulk pharmaceuticals
Li QC, et al.
Journal of Chromatographic Science, 36(3), 119-124 (1998)
Establishment of a knowledge base for prescreening residual solvents in pharmaceuticals
Qin L, et al.
Chromatographia, 59(7-8), 475-480 (2004)
View All Related Papers

Global Trade Item Number

SKUGTIN
PHR1549-3X1.2ML04061834421030