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PHR1736

Venlafaxine Hydrochloride

Name: Venlafaxine Hydrochloride
Brand: SIAL

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Venlafaxine hydrochloride, (+/-)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride, Effexor

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₇NO₂ · HCl

CAS Number:

99300-78-4

Molecular Weight:

313.86

NACRES:

NA.24

PubChem Substance ID:

329823583

UNSPSC Code:

41116107

MDL number:

MFCD03658865

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Properties

Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. Y0000587, traceable to USP 1711268

API family

venlafaxine

CofA

current certificate can be downloaded

packaging

pkg of 1 g

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2

InChI

1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H

InChI key

QYRYFNHXARDNFZ-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530), SLC6A4(6532)

Description

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Venlafaxine Hydrochloride is the hydrochloride salt of venlafaxine, a non-tricyclic antidepressant and serotonin-norepinephrine-dopamine reuptake inhibitor.

Application

Venlafaxine Hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high performance liquid chromatography technique. It is also used as a secondary pharmaceutical standard for the determination of venlafaxine in pharmaceutical formulations using liquid chromatography technique.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Venlafaxine is a dual serotonin-noradrenaline reuptake inhibitor that displays Ki values of 82 and 2480 nM respectively. It is a general class antidepressant.

Venlafaxine is an antidepressant. The mechanism of the antidepresant action of venlafaxine in humans is associated with its potentiation of neurotransmitter activity in the CNS. Venlafaxine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and weak inhibitor of dopamine reuptake. Venlafaxine has no significant activity for muscarinic, histaminergic, or α-1 adrenergic receptors in vitro. Venlafaxine does not possess MAO inhibitor activity.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB7761 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

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Hazard Classifications

Aquatic Chronic 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Differential effects of fluoxetine and venlafaxine in the neural embryonic stem cell test (ESTn) revealed by a cell lineage map.

Victoria C de Leeuw et al.

Neurotoxicology, 76, 1-9 (2019-10-09)

There is a need for in vitro tests for the evaluation of chemicals and pharmaceuticals that may cause developmental neurotoxicity (DNT) in humans. The neural embryonic stem cell test (ESTn) is such an in vitro test that mimics early neural

Stability indicating LC method for the estimation of venlafaxine in pharmaceutical formulations

Makhija NS and Vavia RP

Journal of Pharmaceutical and Biomedical Analysis, 28(6), 1055-1059 (2002)

RP-HPLC estimation of venlafaxine hydrochloride in tablet dosage forms

Baldania LS, et al.

Indian Journal of Pharmaceutical Sciences, 70(1), 124-124 (2008)

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Global Trade Item Number

SKU	GTIN
PHR1736-1G	04061834802143