SMB01318
3-Hydroxydesloratadine
Synonym(s):
3-Hydroxy Desloratadine, Desloratadine 3-Hydroxy Impurity
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About This Item
Empirical Formula (Hill Notation):
C19H19ClN2O
CAS Number:
Molecular Weight:
326.82
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥90%
Form:
solid
description
Modulation and Signaling
Quality Level
assay
≥90%
form
solid
technique(s)
HPLC: suitable
color
pale yellow to off-white
storage temp.
−20°C
SMILES string
Clc1cc2c(cc1)C(=C4CCNCC4)c3ncc(cc3CC2)O
InChI
1S/C19H19ClN2O/c20-15-3-4-17-13(9-15)1-2-14-10-16(23)11-22-19(14)18(17)12-5-7-21-8-6-12/h3-4,9-11,21,23H,1-2,5-8H2
InChI key
NDFMTPISBHBIKE-UHFFFAOYSA-N
General description
3-hydroxy Desloratadine is a major metabolite of desloratadine and loratadine, which are non-sedating tricyclic antagonists of the histamine H1 receptor and antihistamine drugs used to manage allergic rhinitis and chronic idiopathic urticaria.
Application
3-Hydroxy Desloratadine finds application in metabolomics and drug discovery research
Biochem/physiol Actions
3-hydroxydesloratadine formation involves the oxidation of desloratadine by cytochrome P450 (CYP2C8) and subsequent glucuronidation by UDP-glucuronosyltransferase UGT2B10 in cryopreserved human hepatocytes. This pathway leads to the production of 3-hydroxydesloratadine, a major active human metabolite.
Features and Benefits
- High quality compound suitable for multiple research applications
- Compatible with a wide variety of chromatographic and spectrometry techniques
Other Notes
For additional information on our range of Biochemicals, please complete this form.
This product is intended for research purposes only, and it is not meant for human consumption.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Faraz Kazmi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(4), 523-533 (2015-01-18)
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that is widely used for the treatment of allergic rhinitis and chronic idiopathic urticaria. For over 20 years, it has remained a mystery as to which
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SMB01318-1MG | 04065266282047 |
| SMB01318-10MG | 04065266282030 |