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Merck
CN

04243

Potassium phosphate monobasic

meets analytical specification of Ph. Eur., NF, E340, anhydrous, 98-100.5% (calc. to the dried substance)

Synonym(s):

Potassium dihydrogen phosphate, prim.-Potassium phosphate

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About This Item

Linear Formula:
KH2PO4
CAS Number:
Molecular Weight:
136.09
UNSPSC Code:
12161700
eCl@ss:
38070209
PubChem Substance ID:
EC Number:
231-913-4
NACRES:
NA.25
MDL number:
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grade

anhydrous

Quality Level

assay

98-100.5% (calc. to the dried substance)

form

crystalline

quality

meets analytical specification of Ph. Eur., NF, E340

impurities

residual solvents, complies, ≤0.04% KMnO4 red. matter (as O), ≤0.2% in water insoluble matters, ≤10 mg/kg heavy metals (as Pb)

loss

≤1% loss on drying, 130 °C

pH

4.2-4.5 (20 °C, 5%)

pKa (25 °C)

(1) 2.15, (2) 6.82, (3) 12.38 (phosphoric acid)

mp

252.6 °C (lit.)

solubility

H2O: soluble 4.5 parts, alcohol: insoluble

density

2.338 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.001%, fluoride (F-): ≤10 mg/kg, sulfate (SO42-): ≤200 mg/kg

cation traces

As: ≤1 mg/kg, Cd: ≤1 mg/kg, Fe: ≤10 mg/kg, Hg: ≤1 mg/kg, Na: ≤0.1%, Pb: ≤1 mg/kg

suitability

complies for appearance of solution

SMILES string

[K+].OP(O)([O-])=O

InChI

1S/K.H3O4P/c;1-5(2,3)4/h;(H3,1,2,3,4)/q+1;/p-1

InChI key

GNSKLFRGEWLPPA-UHFFFAOYSA-M

Application

Potassium phosphate monobasic was used for separating tobacco protein by using aqueous two-phase extraction.

Biochem/physiol Actions

Potassium phosphate monobasic also referred to as monopotassium phosphate or potassium dihydrogen phosphate is a soluble salt of potassium that serves as a buffering agent. It enhances the solubility of calcium and phosphorus in amino acid plus dextrose solutions and hence assists in improving the mineral balance of parenterally fed low birth weight infants.

Preparation Note

Potassium phosphate monobasic dissolves in 4.5 (approx.) parts of water to yield a solution. It is practically insoluble in alcohol.


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Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable



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P Chessex et al.
The Journal of pediatrics, 116(5), 765-772 (1990-05-01)
Because the monobasic potassium phosphate salt (monobasic) improves the solubility of calcium and phosphorus in amino acid plus dextrose solutions, compared with the current mixtures of monobasic plus dibasic salts (dibasic), we tested the bioavailability and clinical effects of monobasic
Deepa Balasubramaniam et al.
Journal of chromatography. A, 989(1), 119-129 (2003-03-19)
Tobacco has long been considered as a host to produce large quantity of high-valued recombinant proteins. However, dealing with large quantities of biomass is a challenge for downstream processing. Aqueous two-phase extraction (ATPE) has been widely used in purifying proteins
Xinyan Wu et al.
Nature communications, 5, 4961-4961 (2014-09-24)
The PIK3CA gene is frequently mutated in human cancers. Here we carry out a SILAC-based quantitative phosphoproteomic analysis using isogenic knockin cell lines containing 'driver' oncogenic mutations of PIK3CA to dissect the signalling mechanisms responsible for oncogenic phenotypes induced by



Global Trade Item Number

SKUGTIN
04243-1KG04061838629234
04243-4X5KG04061833605257
04243-500G04061838629241
04243-5KG04061838629258
04243-6X1KG04061833605271
04243-6X500G04061833605288