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04273

Sodium phosphate dibasic dodecahydrate

Name: Sodium phosphate dibasic dodecahydrate
Brand: SIGALD

meets analytical specification of Ph. Eur., BP, E339, 98.5-102.5% (T)

Synonym(s):

sec-Sodium phosphate, Disodium hydrogen phosphate dodecahydrate, Disodium phosphate, di-Sodium hydrogen phosphate dodecahydrate

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About This Item

Linear Formula:

Na₂HPO₄ · 12H₂O

CAS Number:

10039-32-4

Molecular Weight:

358.14

PubChem Substance ID:

329747907

UNSPSC Code:

12161700

NACRES:

NA.25

EC Number:

231-448-7

MDL number:

MFCD00149181

Assay:

98.5-102.5% (T)

Form:

crystals

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Properties

Quality Level

200

agency

meets analytical specifications of BP, meets analytical specifications of Ph. Eur.

assay

98.5-102.5% (T)

form

crystals

quality

meets analytical specification of Ph. Eur., BP, E339

impurities

reducing matter, complies, residual solvents, complies, ≤0.001% heavy metals (as Pb), ≤1.0% NaH₂PO₄, 57-61% water (Karl Fischer)

loss

57-61% loss on drying

pH

8.4-9.6 (20 °C, 1%)

anion traces

chloride (Cl^-): ≤10 mg/kg, fluoride (F^-): ≤10 mg/kg, sulfate (SO₄^2-): ≤100 mg/kg

cation traces

As: ≤1 mg/kg, Cd: ≤1 mg/kg, Cu: ≤20 mg/kg, Fe: ≤10 mg/kg, Hg: ≤1 mg/kg, K: ≤50 mg/kg, Pb: ≤4 mg/kg, Zn: ≤10 mg/kg

suitability

complies for appearance of solution

SMILES string

O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O

InChI

1S/2Na.H3O4P.12H2O/c;;1-5(2,3)4;;;;;;;;;;;;/h;;(H3,1,2,3,4);12*1H2/q2*+1;;;;;;;;;;;;;/p-2

InChI key

DGLRDKLJZLEJCY-UHFFFAOYSA-L

Description

Application

Study of the Influence of Alkalizing Components on Matrix Pellets Prepared by Extrusion/Spheronization: This publication examines the effects of sodium phosphate dibasic dodecahydrate as an alkalizing agent in matrix pellets, showcasing its application in improving the physicochemical properties of pellets, which are crucial for controlled drug delivery systems (Hamedelniel EI, Bajdik J, Kasa P Jr, Pintye-Hodi K, 2012).

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.

Matthew H Crouthamel et al.

Arteriosclerosis, thrombosis, and vascular biology, 33(11), 2625-2632 (2013-08-24)

Elevated serum phosphate has emerged as a major risk factor for vascular calcification. The sodium-dependent phosphate cotransporter, PiT-1, was previously shown to be required for phosphate-induced osteogenic differentiation and calcification of cultured human vascular smooth muscle cells (VSMCs), but its

Effect of canagliflozin on blood pressure and adverse events related to osmotic diuresis and reduced intravascular volume in patients with type 2 diabetes mellitus.

Matthew R Weir et al.

Journal of clinical hypertension (Greenwich, Conn.), 16(12), 875-882 (2014-10-21)

The effects of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on blood pressure (BP) and osmotic diuresis- and intravascular volume reduction-related adverse events (AEs) were evaluated using pooled data from four placebo-controlled, phase 3 studies in patients with type 2

A randomized, double blind pilot study to assess the effects of losartan vs. atenolol on the biophysical properties of the aorta in patients with Marfan and Loeys-Dietz syndromes.

George G S Sandor et al.

International journal of cardiology, 179, 470-475 (2014-12-04)

Patients with Marfan (MFS) and Loeys-Dietz (LDS) syndromes have been shown to have abnormal aortic biophysical properties. The purpose of this study was to compare the effects of 12-months of therapy with atenolol or losartan on vascular function in young

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Global Trade Item Number

SKU	GTIN
F5126-5G	04061832423258
04273-1KG	04061838629364
04273-2.5KG	04061838629371
04273-6X1KG	04061833605325
04273-6X2.5KG	04061838629388