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675989

Cyclopentyl methyl ether

greener alternative

contains 50 ppm BHT as inhibitor, ReagentPlus®, ≥99.90%

Synonym(s):

CPME

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About This Item

Empirical Formula (Hill Notation):
C6H12O
CAS Number:
5614-37-9
Molecular Weight:
100.16
NACRES:
NA.21
PubChem Substance ID:
329760630
UNSPSC Code:
12352112
MDL number:
MFCD08276401
Assay:
≥99.90%
Bp:
106 °C/760 mmHg
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Quality Level

100

product line

ReagentPlus®

assay

≥99.90%

form

liquid

contains

50 ppm BHT as inhibitor

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

dilution

(for general lab use)

impurities

≤50 ppm H2O2

bp

106 °C/760 mmHg

mp

-140 °C

density

0.86 g/mL at 25 °C

greener alternative category

Aligned,

SMILES string

COC1CCCC1

InChI

1S/C6H12O/c1-7-6-4-2-3-5-6/h6H,2-5H2,1H3

InChI key

SKTCDJAMAYNROS-UHFFFAOYSA-N

General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. Cyclopentyl methyl ether (CPME) is a greener alternative solvent to many aprotic ether solvents such as tetrahydrofuran (THF), 2-methyl tetrahydrofuran (2-MeTHF), dioxane (carcinogenic), tert-Butyl methyl ether (MTBE), and 1,2-dimethoxyethane (DME) and thus has been enhanced for "Safer Solvents and Auxiliaries".  Click here  for more information.

Application

CPME is a greener alternative solvent and may be used is a broad range of applications such as:

Organic synthesis reactions containing the following reagents and conditions:

  1. Alkali agents
  2. Lewis’s acid-mediated reactions
  3. Organometallic
  4. Reduction and Oxidation
  5. Transition metal catalysts
  6. Azeotropic water removal



Extraction of compounds
Polymer synthesis
Crystallization
Surface coatings

Features and Benefits

  • Synthetic-based sustainable and safer alternative
  • Reduces the number of steps required for production
  • Reduces the amount of water that is required for washing
  • Eliminates the need for co-solvents for product recovery

    It has many properties which make it a safer and greener alternative:
  • Low peroxide formation
  • High boiling point
  • Clean organic-water phase separation
  • Reduced energy to recover

Other Notes

To see other BioRenewable or Greener Solvents

The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent.




Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

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GHS02,GHS07

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

Storage Class

3 - Flammable liquids

flash_point_f

30.2 °F - closed cup - (External MSDS)

flash_point_c

-1 °C - closed cup - (External MSDS)

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
SHBP0748
BCCG8568
BCCG8567
BCCF5560
SHBN7537

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Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents
MacMillan, D.S.; et al.
Green Chemistry (2012)
Cyclopentyl Methyl Ether as a New and Alternative Process Solvent
Watanabe, K.; Yamagiwa, N.; Torisawa, Y.
Organic Process Research & Development, 11 (2007)
Rikako Takahiro et al.
Biological & pharmaceutical bulletin, 38(1), 58-65 (2015-03-07)
The aim of this study was to characterize the kinetics of metabolite formation of the phosphodiesterase type-5 (PDE5) inhibitors sildenafil and tadalafil by CYP3A4, CYP3A5, and CYP3A7 isoforms. The formations of N-desmethyl sildenafil and desmethylene tadalafil were examined using CYP3A

Global Trade Item Number

SKUGTIN
675989-200L04061838152602
675989-4X4L04061832748016
675989-6X1L04061837225017
675989-18L04061837715372
675989-1L04061832747996
675989-4L04061832748009
675989-500ML04061837225000