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01640

Acridine

Name: Acridine
Brand: SIGMA

BioReagent, suitable for fluorescence, ≥97.0% (HPLC)

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₉N

CAS Number:

260-94-6

Molecular Weight:

179.22

PubChem Substance ID:

329747337

eCl@ss:

39210107

UNSPSC Code:

12171500

NACRES:

NA.32

EC Number:

205-971-6

MDL number:

MFCD00005025

Beilstein/REAXYS Number:

120200

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Properties

product line

BioReagent

Quality Level

100

assay

≥97.0% (HPLC)

bp

346 °C (lit.)

mp

106-111 °C, 107-110 °C (lit.)

solubility

ethanol: 0.5 g/10 mL, clear (hot), carbon disulfide: soluble, diethyl ether: soluble, ethanol: soluble, hydrocarbons: soluble

fluorescence

λ_ex 360 nm; λ_em 417 nm in ethanol

suitability

suitable for fluorescence

SMILES string

c1ccc2nc3ccccc3cc2c1

InChI

1S/C13H9N/c1-3-7-12-10(5-1)9-11-6-2-4-8-13(11)14-12/h1-9H

InChI key

DZBUGLKDJFMEHC-UHFFFAOYSA-N

Description

Application

The fluorescence intensity, fluorescence quantum yield, time of decay, and lifetime are dependent upon the solvent. For example, the fluorescence intensity varies from being moderately strong in aqueous solution and very weak in hydrocarbon solvents. Additionally, the quantum yield has been demonstrated to increase with decreasing temperatures, for all solvent conditions.

Analysis Note

In addition to the emission maximum at 417 nm, there are lower maxima at 435, 400 and 460 nm.

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pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H315,H319,H335,H410

pcodes

P261 - P264 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品

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Subnanosecond Time-Resolved Fluorescence of Acridine in Solution

Diverdi, L. A., and Topp, M. R.

The Journal of Physical Chemistry, 88, 3447-3447 (1984)

Broad adaptive immune responses to M. tuberculosis antigens precede TST conversion in tuberculosis exposed household contacts in a TB-endemic setting.

Ulrike K Buchwald et al.

PloS one, 9(12), e116268-e116268 (2014-12-31)

The identification of Mycobacterium-tuberculosis (Mtb) infected individuals remains a challenge due to an insufficient understanding of immune responses detected with the current diagnostic tests for latent tuberculosis i.e. the tuberculin skin test (TST) or IFN-γ release assays (IGRAs) and an

Interference with the production of infectious viral particles and bimodal inhibition of replication are broadly conserved antiviral properties of IFITMs.

Kevin Tartour et al.

PLoS pathogens, 13(9), e1006610-e1006610 (2017-09-29)

IFITMs are broad antiviral factors that block incoming virions in endosomal vesicles, protecting target cells from infection. In the case of HIV-1, we and others reported the existence of an additional antiviral mechanism through which IFITMs lead to the production

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Global Trade Item Number

SKU	GTIN
T21105-50G	04061831836981
T21105-10G	04061831827545
01640-10G	04061838609540
01640-1G	04061826678374
01640-50G	04061838609557