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15759

Poloxamer 188

Name: Poloxamer 188
Brand: SIGMA

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68

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About This Item

CAS Number:

9003-11-6

UNSPSC Code:

12352104

NACRES:

NA.25

MDL number:

MFCD00082049

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Properties

form

solid

Quality Level

200

mol wt

~7680-9510 g/mol

composition

oxyethylene, 79.9-83.7%

impurities

≤5 ppm propylene oxide, ≤0.25% ethylene glycol and diethylene glycol, ≤0.4% total ash, ≤1 ppm ethylene oxide, ≤1.0% water, ≤2 ppm arsenic traces, ≤20 ppm heavy metals, ≤5 ppm dioxan, 50-150 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120, 50/50 in CH₃OH

pH

5.0-7.5 (100 g/L in H₂O), 6.0-7.5 (25 g/L in H₂O)

CMC

0.48 mM

transition temp

cloud point >100 °C

HLB

>24

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

Application

Stabilizing Function of P 188 in Dermal Formulations: Examined for its stabilizing effects on industrial concentrates of dermal hesperidin smartCrystals, P 188 contributed to enhancing the long-term stability of the formulations, relevant for dermal therapeutic interventions (Romero et al., 2015).

Biochem/physiol Actions

Poloxamer 188 is widely used as a thickening agent and gel binder.

Other Notes

The Poloxamer 188 grades are poloxamers from the extensive line of block copolymers.

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Storage Class

11 - Combustible Solids

wgk

WGK 1

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Aggregation behaviors of PEO-PPO-ph-PPO-PEO and PPO-PEO-ph-PEO-PPO at an air/water interface: experimental study and molecular dynamics simulation.

Houjian Gong et al.

Langmuir : the ACS journal of surfaces and colloids, 28(38), 13590-13600 (2012-09-08)

The block polyethers PEO-PPO-ph-PPO-PEO (BPE) and PPO-PEO-ph-PEO-PPO (BEP) are synthesized by anionic polymerization using bisphenol A as initiator. Compared with Pluronic P123, the aggregation behaviors of BPE and BEP at an air/water interface are investigated by the surface tension and

Combined pluronic P85- and ultrasound contrast agents-mediated gene transfection to HepG2 cells.

Xijun Zhang et al.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(6), 842-845 (2011-12-17)

This study examined the effect of P85 (a pluronic block copolymer) and microbubble (MB) ultrasound contrast agents under ultrasound irradiation on gene transfection and expression. The pEGFP plasmids that can encode enhanced green fluorescent protein (pEGFP) served as a report

[Blood plasma protein adsorption capacity of perfluorocarbon emulsion stabilized by proxanol 268 (in vitro and in vivo studies)].

A N Sklifas et al.

Biofizika, 57(2), 317-324 (2012-05-19)

The adsorption abilities of the perfluorocarbon emulsion stabilized by Proxanol 268 were investigated in vitro and in vivo. In vitro, the saturation point for the blood plasma proteins was nearly reached after five minutes of incubation of the emulsion with

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Global Trade Item Number

SKU	GTIN
433047-5G	04061831820287
433047-1G	04061825585222
15759-1KG	04061838743428