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16758

Poloxamer 407

Name: Poloxamer 407
Brand: SIGMA

purified, non-ionic

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)

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About This Item

CAS Number:

9003-11-6

UNSPSC Code:

12352104

NACRES:

NA.25

MDL number:

MFCD00082049

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Properties

Quality Level

100

form

powder

quality

purified

impurities

≤1.0% water

pH

5.0-7.5

solubility

soluble, clear, colorless

cation traces

Al: ≤5 mg/kg, As: ≤0.05 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤50 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤1000 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg

UV absorption

λ: 260 nm A_max: ≤0.3, λ: 280 nm A_max: ≤0..2

suitability

no residue for filter test

storage temp.

2-8°C

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

Description

General description

Poloxamer 407 is a water-soluble, non-ionic surfactant with low toxicity and good solubilizing capacity. This triblock copolymer is composed of a hydrophobic residue of polyoxypropylene (POP) flanked by two hydrophilic units of polyoxyethylene (POE).

Application

Poloxamer 407 has been used:

as an inhibitor of lipoprotein lipase activity to assess hepatic very-low-density lipoprotein (VLDL)- triglyceride (TG) secretion in mice
for VLDL secretion assay in mice
to intraperitoneally inject the mice by dissolving in phosphate buffer saline (PBS) for hepatic triglyceride production

Biochem/physiol Actions

Poloxamer 407 (P407) exhibits reversible gelation properties above a particular polymer concentration and temperature. Poloxamer 407-based sterile injectable formulations serve to be a good candidate for drug delivery. P407 thermo-responsive hydrogels are broadly used as mucosal drug delivery systems as they do not irritate the mucosal membranes. P407 is called an “inactive ingredient” by the U.S. Food and Drug Administration (FDA) for several drug products like oral solutions, suspensions, and inhalation formulations.

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Predicting Silk Fiber Mechanical Properties through Multiscale Simulation and Protein Design.

Nae-Gyune Rim et al.

ACS biomaterials science & engineering, 3(8), 1542-1556 (2017-10-03)

Silk is a promising material for biomedical applications, and much research is focused on how application-specific, mechanical properties of silk can be designed synthetically through proper amino acid sequences and processing parameters. This protocol describes an iterative process between research

Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis.

Camila S Freitas et al.

Parasitology research, 120(1), 321-335 (2020-11-17)

Treatment for visceral leishmaniasis (VL) is hampered mainly by drug toxicity, their high cost, and parasite resistance. Drug development is a long and pricey process, and therefore, drug repositioning may be an alternative worth pursuing. Cardenolides are used to treat

Origin and Function of Stress-Induced IL-6 in Murine Models.

Hua Qing et al.

Cell, 182(2), 372-387 (2020-07-02)

Acute psychological stress has long been known to decrease host fitness to inflammation in a wide variety of diseases, but how this occurs is incompletely understood. Using mouse models, we show that interleukin-6 (IL-6) is the dominant cytokine inducible upon

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Global Trade Item Number

SKU	GTIN
I6758-10G	04061835367061
I6758-1G	04061835367078
I6758-5G	04061835367085
420290-5GM	04055977210828
420291-100GM	04055977210859
420291-1GM	04055977210835
420291-1KG	04055977210842
420291-5GM	07790788050108
420322-10GM	07790788055622
420322-1KG	04055977210569
420322-500GM	07790788050153
70527-3	07790788052690
420322-100GM	07790788050146
420322-1GM	04055977210552
420322-25GM	07790788057817
420322-5GM	04055977210620
16758-250G	04061838749628
I1284-5ML	04061833847640
71300-3	07790788053185
71300-4	04055977253191
70235-4	04055977258585