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317861

Phenyl isothiocyanate

Name: Phenyl isothiocyanate
Brand: SIGMA

99%, liquid, for protein sequencing

Synonym(s):

PITC

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About This Item

Linear Formula:

C₆H₅NCS

CAS Number:

103-72-0

Molecular Weight:

135.19

NACRES:

NA.21

PubChem Substance ID:

57648607

UNSPSC Code:

12352100

EC Number:

203-138-1

MDL number:

MFCD00004798

Beilstein/REAXYS Number:

471392

Assay:

99%

Form:

liquid

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Properties

Product Name

Phenyl isothiocyanate, 99%, for protein sequencing

type

for protein sequencing

Quality Level

100

assay

99%

form

liquid

refractive index

n20/D 1.6515 (lit.)

bp

218 °C (lit.), 221 °C

mp

−21 °C (lit.)

solubility

water: insoluble

density

1.132 g/mL at 20 °C (lit.)

functional group

isothiocyanate

storage temp.

2-8°C

SMILES string

S=C=Nc1ccccc1

InChI

1S/C7H5NS/c9-6-8-7-4-2-1-3-5-7/h1-5H

InChI key

QKFJKGMPGYROCL-UHFFFAOYSA-N

Description

Application

Used for derivatizing N-terminal amino acids of proteins for automated sequential analysis. Synthon for dithiadiazafulvalenes.

Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC.

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pictograms

GHS06,GHS08,GHS05

signalword

Danger

hcodes

H301,H314,H317,H334

pcodes

P261 - P272 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

190.4 °F - closed cup

flash_point_c

88 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Journal of the Chemical Society. Chemical Communications, 601-601 (1993)

Matrix effects in the derivatization of amino acids with naphthalene dicarboxaldehyde, 9-fluorenylmethyl chloroformate and phenylisothiocyanate.

F Lai et al.

BioTechniques, 14(4), 642-649 (1993-04-01)

Pre-column derivatizations of amino acids often present two major challenges: 1) automation, due to the multi-step manipulations for pH control, reagent addition, mixing and extraction, and 2) effect of matrices in the sample such as salts, buffers and surfactants. Both

Determination of phenylisothiocyanate derivatives of amphetamine and its analogues in biological fluids by HPLC-APCI-MS or DAD.

Bogusz MJ, et al.

Journal of Analytical Toxicology, 21(1), 59-69 (1997)

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Global Trade Item Number

SKU	GTIN
317861-1G	04061826692325
317861-5G	04061826692349