37272
7,8-Dihydro-L-biopterin
≥94% (HPLC)
Synonym(s):
2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-3H-pteridin-4-one
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About This Item
Empirical Formula (Hill Notation):
C9H13N5O3
CAS Number:
Molecular Weight:
239.23
UNSPSC Code:
12352116
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
536551
Assay:
≥94% (HPLC)
Quality level:
Quality Level
assay
≥94% (HPLC)
storage temp.
−20°C
SMILES string
C[C@@H](O)[C@@H](O)C1=NC2=C(NC1)N=C(N)NC2=O
InChI
1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,6,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,6-/m1/s1
InChI key
FEMXZDUTFRTWPE-AWFVSMACSA-N
Application
- A Landscape of Metabonomics for Intermingled Phlegm and Blood Stasis and Its Concurrent Syndromes in Stable Angina Pectoris of Coronary Heart Disease.: This study by Zheng et al. (2022) explores the metabolic profiles associated with phlegm and blood stasis syndromes in patients with stable angina pectoris. The research highlights the role of various metabolites, including 7,8-Dihydro-ʟ-biopterin, in the pathophysiology of these syndromes, suggesting potential diagnostic and therapeutic targets (Zheng et al., 2022).
- Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin.: Wang et al. (2002) present the crystal structure of human tryptophan hydroxylase, providing detailed insights into the enzyme′s interaction with cofactors such as 7,8-Dihydro-ʟ-biopterin. This structural information is crucial for developing drugs targeting neurotransmitter biosynthesis pathways (Wang et al., 2002).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Saptarshi Kar et al.
Free radical biology & medicine, 51(7), 1411-1427 (2011-07-12)
Endothelial dysfunction is associated with increase in oxidative stress and low NO bioavailability. The endothelial NO synthase (eNOS) uncoupling is considered an important factor in endothelial cell oxidative stress. Under increased oxidative stress, the eNOS cofactor tetrahydrobiopterin (BH(4)) is oxidized
An L Moens et al.
Journal of molecular and cellular cardiology, 51(4), 564-569 (2011-06-08)
The exogenous administration of tetrahydrobiopterin (BH4), an essential cofactor of nitric oxide synthase (NOS), has been shown to reduce left ventricular hypertrophy, fibrosis, and cardiac dysfunction in mice with pre-established heart disease induced by pressure-overload. In this setting, BH4 re-coupled
Stephen Wedgwood et al.
American journal of physiology. Lung cellular and molecular physiology, 302(6), L616-L626 (2011-12-27)
NADPH oxidase is a major source of superoxide anions in the pulmonary arteries (PA). We previously reported that intratracheal SOD improves oxygenation and restores endothelial nitric oxide (NO) synthase (eNOS) function in lambs with persistent pulmonary hypertension of the newborn
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 37272-10MG | 04061832404202 |
| 37272-50MG | 04061832404219 |