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40234

N,N-Dimethyldodecylamine N-oxide

Name: <I>N,N</I>-Dimethyldodecylamine <I>N</I>-oxide
Brand: SIGMA

BioXtra, ≥99.0% (NT)

Synonym(s):

DDAO, LDAO, Lauryldimethylamine N-oxide

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About This Item

Linear Formula:

CH₃(CH₂)₁₁N(O)(CH₃)₂

CAS Number:

1643-20-5

Molecular Weight:

229.40

UNSPSC Code:

12161902

NACRES:

NA.26

PubChem Substance ID:

57649946

EC Number:

216-700-6

Beilstein/REAXYS Number:

1769927

MDL number:

MFCD00002049

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Properties

Quality Level

200

description

non-ionic, sulfate (ICP): ≤ 50 mg/kg

product line

BioXtra

assay

≥99.0% (NT)

form

powder

mol wt

229.40 g/mol

technique(s)

protein quantification: suitable

impurities

≤0.03% peroxides (as H₂O₂)

CMC

1-2 mM

mp

132-133 °C (lit.)

anion traces

chloride (Cl^-): ≤100 mg/kg

cation traces

Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤100 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

storage temp.

2-8°C

SMILES string

CCCCCCCCCCCC[N+](C)(C)[O-]

InChI

1S/C14H31NO/c1-4-5-6-7-8-9-10-11-12-13-14-15(2,3)16/h4-14H2,1-3H3

InChI key

SYELZBGXAIXKHU-UHFFFAOYSA-N

Description

General description

N,N-Dimethyldodecylamine N-oxide is a non-denaturing zwitterionic surfactant with a critical micelle concentration (CMC) of approximately 1 mM. It is used to solubilize proteins and to study the conformation and molecular interactions of macromolecules.

Application

N,N-Dimethyldodecylamine N-oxide has been used in the cell lysis and resuspension of cell pellets for western blot analysis.

pictograms

GHS05,GHS07,GHS09

signalword

Danger

hcodes

H302,H315,H318,H410

pcodes

P264 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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A 10,000-fold nuclear hyperpolarization of a membrane protein in the liquid phase via a solid-state mechanism.

Eugenio Daviso et al.

Journal of the American Chemical Society, 133(42), 16754-16757 (2011-10-04)

Several techniques rely on electron-nuclear interactions to boost the polarization of nuclear spins in the solid phase. Averaging out of anisotropic interactions as a result of molecular tumbling strongly reduces the applicability of such hyperpolarization approaches in liquids. Here we

Effect of detergent concentration on the thermal stability of a membrane protein: The case study of bacterial reaction center solubilized by N,N-dimethyldodecylamine-N-oxide.

Gerardo Palazzo et al.

Biochimica et biophysica acta, 1804(1), 137-146 (2009-09-30)

We report on the response of reaction center (RC) from Rhodobacter sphaeroides (an archetype of membrane proteins) to the exposure at high temperature. The RCs have been solubilized in aqueous solution of the detergent N,N-dimethyldodecylamine-N-oxide (LDAO). Changes in the protein

"Self-immolative" spacer for uncaging with fluorescence reporting.

Raphaël Labruère et al.

Angewandte Chemie (International ed. in English), 51(37), 9344-9347 (2012-08-30)

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Global Trade Item Number

SKU	GTIN
40234-25G	04061835541324
40234-5G	04061835515479