46946
Fluorescein isothiocyanate–dextran
average mol wt 150,000, (FITC:Glucose = 1:160)
Synonym(s):
FITC-Dextran 150, FITC–Dextran
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About This Item
form
solid
Quality Level
mol wt
average mol wt 150,000
composition
(FITC:Glucose = 1:160)
extent of labeling
~0.004 mol/mol FITC glucose
solubility
H2O: 25 mg/mL, slightly hazy, very deep yellow-orange
fluorescence
λex 492 nm; λem 518 nm in 0.1 M phosphate pH 8.0
storage temp.
2-8°C
Application
Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran (FITC-Dextran 150) is use as a fluorescent probe to study cell permeability. FITC-Dextran 150 is useful to study processes that affect the permeability of the blood brain barrier (BBB) and microvascular structures. FITC-Dextran 150 is used in fluorescence microlymphography.
Other Notes
Commonly utilized as a macromolecular fluorochrome in inflammatory studies
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signalword
Warning
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
hcodes
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Fátima Z G A Cyrino et al.
Clinical and experimental pharmacology & physiology, 31(3), 159-162 (2004-03-11)
1. The present study was designed to evaluate the effect of micronization on the protective effect of the purified flavonoid fraction (MPFF) on increases in macromolecular permeability induced by ischaemia-reperfusion in the hamster cheek pouch microcirculation. 2. Male hamsters (Mesocricetus
D M Gawlowski et al.
Microvascular research, 37(1), 1-15 (1989-01-01)
Fluorescein-labeled dextran MW 150K (FITC-Dx 150) is commonly utilized as a macromolecular fluorochrome in inflammatory studies. We examined the influence of FITC-Dx 150 on leukocyte activity as assessed by adherence to cheek pouch microvessels. Transcapillary exchange was evaluated as fluorochrome
Takayuki Ishii et al.
Brain research, 1321, 164-168 (2010-01-26)
Ischemia-reperfusion injury is induced by recovery of blood flow after ischemia. This phenomenon is a main cause of ischemic brain injury. The integrity of the blood-brain barrier (BBB) fails after cerebral ischemia and reperfusion. Further elucidation of this phenomenon promotes
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 46946-5G-F | 04061833354070 |
| 46946-100MG-F | 04061832358918 |
| 46946-500MG-F | 04061832532189 |